News | August 31, 2022
Phage Therapy
Natural virus predators offer potential alternative to antibiotics
Academics plan to roll out therapy widely in Australia: Researchers at the University of Sydney, Western Sydney Local Health District and the Westmead Institute for Medical Research are developing a therapeutic solution to antimicrobial resistance that predates the discovery and wide usage of antibiotics…
News | August 17, 2022
Phage Therapy
A therapy from the past could hold the key to beating antibiotic resistance in the future
An expert team, led by Director of the Centre of Infectious Diseases and Microbiology at the Westmead Institute for Medical Research (WIMR) Professor Jon Iredell, is developing a key alternative to antibiotics and central to the treatment are phages…
Twitter | July 15, 2022
Phage Therapy
Twitter | July 05, 2022
FundingPhage Therapy
Publication | June, 2022
Phage Therapy

Phage Therapy of Mycobacterium Infections: Compassionate-use of Phages in Twenty Patients with Drug-Resistant Mycobacterial Disease

Clinical Infectious Diseases
Authors: Rebekah M. Dedrick, Bailey E. Smith, Madison Cristinziano, Krista G. Freeman, Deborah Jacobs-Sera, Yvonne Belessis, A. Whitney Brown, Keira A. Cohen, Rebecca M. Davidson, David van Duin, Andrew Gainey, Cristina Berastegui Garcia, C.R. Robert George, Ghady Haidar, Winnie Ip, Jonathan Iredell, Ameneh Khatami, Jessica S. Little, Kirsi Malmivaara, Brendan J. McMullan, David E. Michalik, Andrea Moscatelli, Jerry A. Nick, Maria G. Tupayachi Ortiz, Hari M. Polenakovik, Paul D. Robinson, Mikael Skurnik, Daniel A. Solomon, James Soothill, Helen Spencer, Peter Wark, Austen Worth, Robert T. Schooley, Constance A. Benson, Graham F. Hatfull
News | June 17, 2022 | Phage WA
Phage WA Site Launched cover
Phage WA Site Launched
Leading the fight against Antimicrobial Resistance (AMR) in Western Australia: The WA Phage website showcases the research journey and outputs of WA researchers from the Wal-yan Respiratory Research Centre at the Telethon Kids Institute. The Phage WA website connects us with our community and provides up to date information on our collective mission to tackle anti-microbial resistance (AMR) through phage therapy.
Publication | 2020
Phage TherapyClinical trialSepsis

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

Nature Microbiology
Authors: Aleksandra Petrovic Fabijan, Ruby CY Lin, Josephine Ho, Susan Maddocks, Nouri L. Ben Zakour, and Jonathan R. Iredell.
Publication | February, 2021
Phage TherapyCliniciansReview paper

A Phage Therapy Guide for Clinicians and Basic Scientists: Background and Highlighting Applications for Developing Countries

Frontiers in Microbiology
Authors: Ali Khalid, Ruby C. Y. Lin and Jonathan R. Iredell
Publication | January, 2020
AbstractPhage Therapy

Bacteriophage therapy in the critically ill

Australian Critical Care
Authors: Josephine Ho, Aleksandra Petrovic Fabijan, Ruby CY. Lin, Susan Maddocks, Jonathan Iredell
Publication | January, 2021
AcinetobacterPhage-resistanceResearch paper

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

Nature Microbiology
Authors: Fernando Gordillo Altamirano, John H. Forsyth, Ruzeen Patwa, Xenia Kostoulias, Michael Trim, Dinesh Subedi, Stuart K. Archer, Faye C. Morris, Cody Oliveira, Luisa Kielty, Denis Korneev, Moira K. O’Bryan, Trevor J. Lithgow, Anton Y. Peleg & Jeremy J. Barr
Publication | March, 2020
Phage isolationKlebsiellaPhage TherapyResearch paper

Isolation and Characterization of Klebsiella Phages for Phage Therapy

PHAGE
Authors: Eleanor M. Townsend, Lucy Kelly, Lucy Gannon, George Muscatt, Rhys Dunstan, Slawomir Michniewski, Hari Sapkota, Saija J. Kiljunen, Anna Kolsi, Mikael Skurnik, Trevor Lithgow, Andrew D. Millard, and Eleanor Jameson
Publication | May, 2021
Phage biologyResearch paper

Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis

bioRxiv | pre-print
Authors: Wai Hoe Chin, Ciaren Kett, Oren Cooper, Deike Müseler, Yaqi Zhang, Rebecca Bamert, Ruzeen Patwa, Laura C. Woods, Citsabehsan Devendran, Joe Tiralongo, Trevor Lithgow, Mike J. McDonald, Adrian Neild, Jeremy J. Barr
Publication | September, 2021
Antibiotic resistanceUropathogens

Antibiotic resistance in uropathogens across northern Australia 2007–20 and impact on treatment guidelines

JAC Antimicrobial Resistance
Authors: Will Cuningham, Shalinie Perera, Sonali Coulter, Graeme R Nimmo, Trent Yarwood, Steven Y C Tong, Teresa M Wozniak
Publication | April, 2021
Phage biobankOpinion paper

Phage Biobank: Present Challenges and Future Perspectives

Current Opinions in Biotechnology
Authors: Ruby CY Lin, Jessica C Sacher, Pieter-Jan Ceyssens, Jan Zheng, Ali Khalid, Jonathan R Iredell, The Australian Phage Biobanking Network.
Publication | November, 2020
PediatricsPhage TherapyClinical trialResearch paper

Therapeutic monitoring of the host-bacterium-phage interaction in a child

Research Square | Pre-print
Authors: Ameneh Khatami, Ruby Lin, Aleksandra Petrovic-Fabijan, Sivan Alkalay-Oren, Sulaiman Almuzam, Philip Britton, Michael Brownstein, Quang Dao, Joseph Fackler, Ronen Hazan, Bri’Anna Horne, Ran Nir-Paz, Jonathan Iredell
Publication | March, 2019
Phage TherapyResearch paper

Bacteriophage therapy for severe infections

Microbiology Australia
Authors: Carola Venturini, Aleksandra Petrovic Fabjian and Ruby CY Lin
Publication | May, 2021
Research paperPhage Machine-LearningPhage biology

Component Parts of Bacteriophage Virions Accurately Defined by a Machine-Learning Approach Built on Evolutionary Features

ASM Journal: mSystems
Authors: Tze Y. Thung, Murray E. White, Wei Dai, Jonathan J. Wilksch, Rebecca S. Bamert, Andrea Rocker, Christopher J. Stubenrauch, Daniel Williams, Cheng Huang, Ralf Schittelhelm, Jeremy J. Barr, Eleanor Jameson, Sheena McGowan, Yanju Zhang, Jiawei Wang, Rhys A. Dunstan, and Trevor Lithgow
Publication | May, 2021
StaphylococcusMRSAClinical

Annals for Hospitalists Inpatient Notes - Clinical Pearls—Methicillin-Resistant Staphylococcus aureus Bacteremia

Annals of Internal Medicine
Authors: Steven Y.C. Tong
Publication | July, 2020
Phage TherapyStaphylococcusAnimal model

Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus

BMC Microbiology
Authors: Legesse Garedew Kifelew, Morgyn S. Warner, Sandra Morales, Lewis Vaughan, Richard Woodman, Robert Fitridge, James G. Mitchell & Peter Speck
Publication | September, 2021
Review paperRespiratory Tract infectionsPhage Therapy

Phage Therapy for Multi-Drug Resistant Respiratory Tract Infections

MDPI: Viruses
Authors: Joshua J. Iszatt, Alexander N. Larcombe, Hak-Kim Chan, Stephen M. Stick, Luke W. Garratt and Anthony Kicic.
Publication | August, 2021
Clinical trialPediatricsImmune responsePhage Therapy

Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child

EMBO Molecular Medicine
Authors: Ameneh Khatami, Ruby C Y Lin, Aleksandra Petrovic-Fabijan, Sivan Alkalay-Oren, Sulaiman Almuzam, Philip N Britton, Michael J Brownstein, Quang Dao, Joe Fackler, Ronen Hazan, Bri’Anna Horne, Ran Nir-Paz, Jonathan R Iredell
Publication | December, 2020
Phage VirulenceAntibiotic synergyResearch paper

Rapid automated system for bacteriophage virulence and antibiotic synergy testing – The ‘phago-antibiogram’

International Journal of Infectious Diseases
Authors: A. Khalid, A.P. Fabijan, S. Maddocks, R.C.Y. Lin J.R. Iredell
Publication | February, 2020
Clinical trialMRSAAntibiotics

Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia A Randomized Clinical Trial

JAMA Network
Authors: Steven Y. C. Tong, David C. Lye, Dafna Yahav
Publication | June, 2020
Cystic FibrosisPhage isolationPseudomonasStaphylococcusPediatrics

Isolating and characterising phages against Pseudomonas aeruginosa and Staphylococcus aureus in children with cystic fibrosis

Journal of Cystic Fibrosis
Authors: Jagdev Singh, Dinesh Subedi, Fernando Lautaro Gordillo Altamirano, Ruzeen Patwa, Hiran Selvadurai, Jeremy Barr, Ameneh Khatami
Publication | May, 2020
Research paperBiofilmsStaphylococcusPseudomonasPhage Therapy

Efficacy of Lytic Phage Cocktails on Staphylococcus aureus and Pseudomonas aeruginosa in Mixed-Species Planktonic Cultures and Biofilms

MDPI: Viruses
Authors: Legesse Garedew Kifelew, Morgyn S. Warner, Sandra Morales, Nicky Thomas, David L. Gordon, James G. Mitchell, and Peter G. Speck.
Publication | November, 2021
Phage host rangePseudomonasScreening assayResearch paper

Development and validation of a miniaturized bacteriophage host range screening assay against antibiotic resistant Pseudomonas aeruginosa

Journal of Microbiological Methods
Authors: Renee Nicole Ng, Lucinda Jane Grey, Andrew Vaitekenas, Samantha Abagail McLean, Jack Dylan Rudruma, Daniel Rodolfo Laucirica, Matthew Wee-Peng Poh, Jessica Hillas, Scott Glenn Winslow, Joshua James Iszatt, Thomas Iosifidis, Anna Sze Tai, Patricia Agudelo-Romero, Barbara Jane Chang, Stephen Michael Stick, Anthony Kicic.
Publication | April, 2020
Review paperPhage Therapy

Phage therapy for severe bacterial infections: a narrative review

The Medical Journal of Australia
Authors: Aleksandra Petrovic Fabijan, Ali Khalid, Susan Maddocks, Josephine Ho, Timothy Gilbey, Indy Sandaradura, Ruby CY Lin, Nouri Ben Zakour, Carola Venturini, Bethany Bowring, Jonathan R Iredell
Publication | August, 2021
KlebsiellaResearch paperPhage biology

Mechanistic Insights into the Capsule-Targeting Depolymerase from a Klebsiella pneumoniae Bacteriophage

ASM Journal: Microbiology Spectrum
Authors: Rhys A. Dunstan, Rebecca S. Bamert, Matthew J. Belousoff, Francesca L. Short, Christopher K. Barlow, Derek J. Pickard, Jonathan J. Wilksch, Ralf B. Schittenhelm, Richard A. Strugnell, Gordon Dougan, and Trevor Lithgow
Publication | October, 2021
Antibiotic resistanceStaphylococcusMRSA

How I manage a patient with MRSA bacteraemia

Clinical Microbiology & Infection
Authors: Joshua S. Davis, Neta Petersiel, Steven YC. Tong
Publication | October, 2021
Review paperPhage TherapyPediatrics

Phage therapy in pediatrics: the way forward for difficult-to-treat infections?

Expert Review of Anti-infective Therapy
Authors: Annaleise R. Howard-Jones, Jonathan R. Iredell & Ameneh Khatami
Publication | September, 2021
Phage biobank

How Many Health Research Biobanks Are There?

Biopreservation and Biobanking
Authors: Sheila O'Donoghue, Simon Dee, Jennifer A. Byrne, and Peter Hamilton Watson
Publication | November, 2020
Respective paperPhage Therapy

The Promise of viral phage therapy in hernia mesh infection, is this the biological ‘silver bullet’ of the future?

ANZ Journal of Surgery
Authors: Peter Speck, Morgyn Warner, Jason Clark, ,Anita Jacombs, Alex Karatassas, Chris Hensman
Publication | August, 2020
Policy PerspectivePhage biobank

Improving Academic Biobank Value and Sustainability Through an Outputs Focus

Value in Health
Authors: Amanda Rush, Daniel R. Catchpoole, Rod Ling, Andrew Searles, Peter H. Watson, Jennifer A.Byrne
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Phage Australia is a national network of phage researchers and clinician scientists who aim to professionalise phage therapy as the third major intervention for infectious diseases, after vaccines and antibiotics.

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