{"achievements_table":[{"rows":[{"id":"54f9de99-aa21-4170-8d50-821e22d2a05a","Published":true,"Type":"Publication","Description":"Bacteriophages (phages) are viruses with the ability to infect bacteria, and they have recently attracted substantial attention as potential therapeutic alternatives or adjuvants to antibiotic therapy due to the global urgency of antimicrobial resistance. Antibiotics have been the clinical ‘gold standard’ for treating bacterial infections, and their pharmacokinetics/pharmacodynamics (PK/PD) have been extensively investigated over the past decades. Unfortunately, there has been a significant lack of research on the PK/PD of phage therapy, severely hindering its clinical translation. Recognising this as a major hurdle, excellent reviews summarising the available literature on phage PK/PD have been published over recent years. The aim of this present narrative review is to discuss the PK/PD challenges with the clinical translation of phage therapy and address the voids that need to be filled.","Journal":["Clinical Microbiology and Infection"],"Profiles":"aleksandra-petrovic-fabijan, kim-chan, jian-li","URL":"https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00046-0/fulltext","Tags":["Phage Therapy"," PK/PD"," Review Paper"],"Authors":"Sue C. Nang, Yu-Wei Lin, Aleksandra Petrovic Fabijan, Rachel Y.K. Chang, Gauri G. Rao, Jonathan Iredell, Hak-Kim Chan, Jian Li","Name":"Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation"},{"id":"f2430b5c-3cd8-4d4b-b68f-7657eec17ced","Published":true,"Type":"Publication","Description":"Staphylococcus aureus is a leading cause of bacteraemia and endocarditis in which intraclonal genetic variation, but not true polyclonal bacteraemia, is well documented. We describe a case of 36-year-old women with simultaneous and persistent bacteremia from two strains of Staphylococcus aureus that probably would have gone unrecognised because of the identical antibiotic profiles if had we not used bacteriophage susceptibility (“phage typing”) to further characterise the strains. In this patient, the dual bacteraemia was followed months later by another bacteraemia that likely would have been deemed a relapse of the original infection, except that we used similar methods to identify a third and unrelated strain. Our patient eventually responded well to antibiotics, and her bacteriophage therapy probably contributed little to that recovery. However, bacteriophage therapy required that we identify the strain of S. aureus causing her bacteraemia, and that requirement led directly to our identification of dual strains with identical antibiotic susceptibilities. Because of this experience, we alert other clinicians to the possibility of polyclonal infections with S. aureus. When bacteraemia is suspected, clinicians often pick a single colony or a few colonies from the original culture because prompt identification of the organism is critical and this practice provides a faster turnaround time. We caution that it might not identify different strains with different antibiotic sensitivities when polyclonal infections are present.","Journal":["Annals of Internal Medicine"],"Profiles":"aleksandra-petrovic-fabijan, nouri-ben-zakour, jon-iredell","URL":"https://www.acpjournals.org/doi/epdf/10.7326/L19-0369","Tags":["Phage Therapy"," Polyclonal Bacteraemia"," Staphylococcus aureus"],"Org":"Westmead Hospital, Westmed Institute for Medical Research","Authors":"Aleksandra Petrovic Fabijan, Nouri L. Ben Zakour, Josephine Ho, Ruby CY Lin, Jonathan Iredell, Westmead Bacteriophage Therapy Team (WBTT) and AmpliPhi Biosciences Corporation","Name":"Polyclonal Staphylococcus aureus Bacteraemia"},{"id":"566ba630-6ef7-4e81-ab1c-1faa915432f6","Published":true,"Type":"Publication","Description":"Bacterial L-forms require specialized culture techniques and are neither widely reported nor well understood in human infections. To date, most of the studies have been conducted on Gram-positive and stable L-form bacteria, which usually require mutagenesis or long-term passages for their generation. Here, using an adapted osmoprotective growth media, we provide evidence that pathogenic E. coli can efficiently switch to L-forms and back to a cell-walled state, proliferating aerobically in supratherapeutic concentrations of antibiotics targeting cell walls with few or no changes in their DNA sequences. Our work demonstrates that L-form switching is an effective adaptive strategy in stressful environments and can be expected to limit the efficacy of β-lactam and phages for many important infections.","Journal":["Microbiology Spectrum"],"Profiles":"aleksandra-petrovic-fabijan","URL":"https://journals.asm.org/doi/10.1128/spectrum.02419-22","Tags":["L-forms"," Antibiotic resistance"," Phages"," Escherichia coli"],"Org":"Westmead Institute for Medical Research","Authors":"Aleksandra Petrovic Fabijan, David Martinez-Martin, Carola Venturini, Katarzyna Mickiewicz, Neftali Flores-Rodriguez, Jeff Errington, Jonathan Iredell","Name":"L-Form Switching in Escherichia coli as a Common β-Lactam Resistance Mechanism","Date":""},{"id":"ea3b3ff3-e4ff-437a-a4ed-6020aec50b12","Published":true,"Type":"Publication","Description":"Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous in nature, phages can be used to treat bacterial infections (phage therapy), including refractory infections and those resistant to antibiotics. However, despite an abundance of anecdotal evidence of efficacy, significant hurdles remain before routine implementation of phage therapy into medical practice, including a dearth of robust clinical trial data. Phage–bacterium interactions are complex and diverse, characterized by co-evolution trajectories that are significantly influenced by the environments in which they occur (mammalian body sites, water, soil, etc.). An understanding of the molecular mechanisms underpinning these dynamics is essential for successful clinical translation. This review aims to cover key aspects of bacterium–phage interactions that affect bacterial killing by describing the most relevant published literature and detailing the current knowledge gaps most likely to influence therapeutic success.","Journal":["EMBO Molecular Medicine"],"Profiles":"carola-venturini","URL":"https://www.embopress.org/doi/full/10.15252/emmm.202012435","Tags":["Phage biology"," Phage Therapy"," Phage-bacterium dynamics"," Antimicrobials"],"Org":"Westmead Institute for Medical Research","Authors":"Carola Venturini, Aleksandra Petrovic Fabijan, Alicia Fajardo Lubian, Stefanie Barbirz, Jonathan Iredell","Name":"Biological foundations of successful bacteriophage therapy","Date":""},{"id":"17fb0201-d8e9-4459-adc7-28a3b5e825aa","Published":true,"Type":"Publication","Description":"The first phage therapy course jointly organised by ESCMID (European Society of Clinical Microbiology and Infectious Diseases) and ESGNTA (ESCMID Study Group for Non-traditional Antibacterial Therapy) and includes four sessions with cutting-edge scientific talks in the field of personalised phage therapy : (1) therapeutic monitoring (2) immune response to bacteriophages (3) formulation and administration of bacteriophages for therapy, and (4) current state and prospects of oral phage therapy, followed by live Q&A sessions and panel discussion.","Journal":["ESCMID Online Course 2022"],"Profiles":"aleksandra-petrovic-fabijan","URL":"https://eacademy.escmid.org/escmid/#!*menu=6*browseby=3*sortby=2*ce_id=2271","Tags":["Online Course"," Phage therapy"," ESCMID"," ESGNTA"],"Org":"ESCMID, ESGNTA, Westmead Institute for Medical Research","Authors":"Aleksandra Petrovic Fabijan, Jonathan Iredell","Name":"Personalised phage therapy: basic principles of monitoring and treatment","Date":"","Cover":"https://dl.phage.directory/escmid.png"},{"id":"c00e5fcc-bfc6-4440-a8b8-c51e7a181985","format":{"copied_from_pointer":{"id":"d49d38b9-3af5-4b41-8a7d-475b631ce272","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"News","Description":"Academics plan to roll out therapy widely in Australia: Researchers at the University of Sydney, Western Sydney Local Health District and the Westmead Institute for Medical Research are developing a therapeutic solution to antimicrobial resistance that predates the discovery and wide usage of antibiotics… [Link to Paper](https://www.escmid.org/fileadmin/src/media/PDFs/1Dates_Events/event_flyers/ESGNTA_Course22_web.pdf)","Profiles":"jon-iredell,ameneh-khatami,ruby-lin","URL":"https://www.sydney.edu.au/news-opinion/news/2022/08/31/natural-virus-predators-offer-potential-alternative-to-antibioti.html?campaign=BIENCO&source=twitter&area=medicine-health&a=public&type=p&pid=phage","Tags":["Phage Therapy"],"Name":"Natural virus predators offer potential alternative to antibiotics","Date":{"type":"date","start_date":"2022-08-31"}},{"id":"90dfc69b-1ce3-4393-8b0c-6170ec50e72e","Published":true,"Type":"News","Description":"An expert team, led by Director of the Centre of Infectious Diseases and Microbiology at the Westmead Institute for Medical Research (WIMR) Professor Jon Iredell, is developing a key alternative to antibiotics and central to the treatment are phages…","Profiles":"jon-iredell,ameneh-khatami,ruby-lin","URL":"https://www.medicalresearch.nsw.gov.au/a-therapy-from-the-past-could-hold-the-key-to-beating-antibiotic-resistance-in-the-future/","Tags":["Phage Therapy"],"Name":"A therapy from the past could hold the key to beating antibiotic resistance in the future","Date":{"type":"date","start_date":"2022-08-17"}},{"id":"97a5cdd6-0d2f-4cd8-96f8-89bd2ff57778","Published":true,"Type":"Twitter","URL":"https://twitter.com/kids_research/status/1547813178448691201?s=12&t=8j_vJZaMKUf2C_xyIGNxjQ","Tags":["Phage Therapy"],"Name":"

Phage therapy changed the life of this brave Sydney teen, after years of treatment for a stubborn infection. Read more 👇 @SCHNkids @WestSydHealth @WestmeadInst @PhageAustralia #kidsresearch #phagetherapy #phage #cysticfibrosis https://t.co/PMxVPT2B6f
— Kids Research (@kids_research) July 15, 2022

","Date":{"type":"date","start_date":"2022-07-15"}},{"id":"9b248287-600e-4e70-9fdd-889bf24fa016","Published":true,"Type":"Twitter","Profiles":"anthony-kicic","URL":"https://twitter.com/dranthonykicic/status/1544170888152907776?s=12&t=Nv6DR2JhY15aaHeV8JIN2A","Tags":["Funding","Phage Therapy"],"Name":"

Excited to have received funding to create a phage production facility for those severely ill. @telethonkids @WalyanCentre, @PhageAustralia

Reading: Future Health Research and Innovation Fund - Innovation Seed Fund grant recipients https://t.co/WytRgGSOg9 #Future
— Anthony Kicic (@DrAnthonyKicic) July 5, 2022

","Date":{"type":"date","start_date":"2022-07-05"}},{"id":"e5e8423a-7b39-45cf-bc82-0d0280eb5b0f","format":{"copied_from_pointer":{"id":"17fb0201-d8e9-4459-adc7-28a3b5e825aa","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Clinical Infectious Diseases"],"Profiles":"ameneh-khatami,jon-iredell","URL":"https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac453/6604409","Tags":["Phage Therapy"],"Publication date":"June, 2022","Authors":"Rebekah M. Dedrick, Bailey E. Smith, Madison Cristinziano, Krista G. Freeman, Deborah Jacobs-Sera, Yvonne Belessis, A. Whitney Brown, Keira A. Cohen, Rebecca M. Davidson, David van Duin, Andrew Gainey, Cristina Berastegui Garcia, C.R. Robert George, Ghady Haidar, Winnie Ip, Jonathan Iredell, Ameneh Khatami, Jessica S. Little, Kirsi Malmivaara, Brendan J. McMullan, David E. Michalik, Andrea Moscatelli, Jerry A. Nick, Maria G. Tupayachi Ortiz, Hari M. Polenakovik, Paul D. Robinson, Mikael Skurnik, Daniel A. Solomon, James Soothill, Helen Spencer, Peter Wark, Austen Worth, Robert T. Schooley, Constance A. Benson, Graham F. Hatfull","Name":"Phage Therapy of Mycobacterium Infections: Compassionate-use of Phages in Twenty Patients with Drug-Resistant Mycobacterial Disease"},{"id":"4e4a9019-5988-489b-8ec5-2c9083f50c97","format":{"copied_from_pointer":{"id":"9e715b4e-7164-43e9-aa4c-fad39600314e","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"News","Description":"Leading the fight against Antimicrobial Resistance (AMR) in Western Australia: The WA Phage website showcases the research journey and outputs of WA researchers from the Wal-yan Respiratory Research Centre at the Telethon Kids Institute. The Phage WA website connects us with our community and provides up to date information on our collective mission to tackle anti-microbial resistance (AMR) through phage therapy.","Profiles":"anthony-kicic","URL":"https://walyanrespiratory.telethonkids.org.au/projects/phage-wa/","Org":"Phage WA","Name":"Phage WA Site Launched","Date":{"type":"date","start_date":"2022-06-17"},"Cover":"https://dl.phage.directory/.attachments/5b1977d4e6052caca5bfa238cc742cfc/b183e50a/current-research-transformed.webp"},{"id":"1238b74d-eb18-4e05-811d-ed0c684762a9","Published":true,"Type":"Publication","Journal":["Nature Microbiology"],"Profiles":"aleksandra-petrovic-fabijan","URL":"https://www.nature.com/articles/s41564-019-0634-z","Tags":["Phage Therapy","Clinical trial","Sepsis"],"Publication date":"2020","Authors":"Aleksandra Petrovic Fabijan, Ruby CY Lin, Josephine Ho, Susan Maddocks, Nouri L. Ben Zakour, and Jonathan R. Iredell.","Name":"Safety of bacteriophage therapy in severe Staphylococcus aureus infection","First author":"Aleksandra Petrovic Fabijan"},{"id":"9e715b4e-7164-43e9-aa4c-fad39600314e","format":{"copied_from_pointer":{"id":"c3d5ee69-8729-4ca9-8e80-2ef574a71805","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":false,"Type":"Twitter","URL":"https://twitter.com/UWAresearch/status/1529722186960777217?s=20&t=dLtH8ywtI-LTM6nbxYo89A","Name":"

Congratulations to @jcarapetis @telethonkids Executive Director & Winthrop Professor at @uwanews - elected as a new Fellow of the prestigious @Science_Academy in recognition of his pioneering, paradigm-shifting expertise in infectious diseases

READ: https://t.co/vZvLYMgEMs pic.twitter.com/iLRyEeh62k
— UWA Research (@UWAresearch) May 26, 2022

"},{"id":"295ab63b-77d0-451a-aac7-6578b1dcf670","Type":"News","Description":"We just launched the first version of our site!","Profiles":"phage-australia","URL":"https://phageaustralia.org","Org":"Phage Australia","Name":"Website Launched","Date":{"type":"date","start_date":"2022-05-28"}},{"id":"21826a6b-86bb-4560-981d-9a23f8d10b62","format":{"copied_from_pointer":{"id":"f1b41dd5-992e-43d1-92c3-8e002242702b","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Frontiers in Microbiology"],"Profiles":"ruby-lin,jon-iredell","URL":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904893/","Tags":["Phage Therapy","Clinicians","Review paper"],"Publication date":"February, 2021","Authors":"Ali Khalid, Ruby C. Y. Lin and Jonathan R. Iredell","Name":"A Phage Therapy Guide for Clinicians and Basic Scientists: Background and Highlighting Applications for Developing Countries","First author":"Ali Khalid"},{"id":"646a0c51-7714-489d-b6d8-9b8ed3588b25","format":{"copied_from_pointer":{"id":"d84b0e6f-7ba2-4889-8f5c-a40364a1dabb","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Australian Critical Care"],"Profiles":"ruby-lin,jon-iredell","URL":"https://www.australiancriticalcare.com/article/S1036-7314(20)30089-8/fulltext","Tags":["Abstract","Phage Therapy"],"Publication date":"January, 2020","Authors":"Josephine Ho, Aleksandra Petrovic Fabijan, Ruby CY. Lin, Susan Maddocks, Jonathan Iredell","Name":"Bacteriophage therapy in the critically ill","First author":"Josephine Ho"},{"id":"0811bf6c-0129-40e2-836a-e6ea43e57921","format":{"copied_from_pointer":{"id":"e5cb6e6d-4438-42c9-a3b7-e50e9f6c80d0","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Nature Microbiology"],"Profiles":"trevor-lithgow,anton-peleg,jeremy-barr","URL":"https://www.nature.com/articles/s41564-020-00830-7","Tags":["Acinetobacter","Phage-resistance","Research paper"],"Publication date":"January, 2021","Authors":"Fernando Gordillo Altamirano, John H. Forsyth, Ruzeen Patwa, Xenia Kostoulias, Michael Trim, Dinesh Subedi, Stuart K. Archer, Faye C. Morris, Cody Oliveira, Luisa Kielty, Denis Korneev, Moira K. O’Bryan, Trevor J. Lithgow, Anton Y. Peleg & Jeremy J. Barr","Name":"Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials","First author":"Fernando Gordillo Altamirano"},{"id":"20091c19-561e-4a68-b241-1ead23e56974","format":{"copied_from_pointer":{"id":"ce9cfdf1-ac19-4d3c-8d51-f7d1117f1779","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["PHAGE"],"Profiles":"trevor-lithgow","URL":"https://www.liebertpub.com/doi/full/10.1089/phage.2020.0046","Tags":["Phage isolation","Klebsiella","Phage Therapy","Research paper"],"Publication date":"March, 2020","Authors":"Eleanor M. Townsend, Lucy Kelly, Lucy Gannon, George Muscatt, Rhys Dunstan, Slawomir Michniewski, Hari Sapkota, Saija J. Kiljunen, Anna Kolsi, Mikael Skurnik, Trevor Lithgow, Andrew D. Millard, and Eleanor Jameson","Name":"Isolation and Characterization of Klebsiella Phages for Phage Therapy","First author":"Eleanor M. Townsend"},{"id":"82e9320d-d900-41a4-ba34-f360d3d17271","format":{"copied_from_pointer":{"id":"db9f4f1f-7340-4e4d-a78c-51022fb679aa","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["bioRxiv | pre-print"],"Profiles":"jeremy-barr,trevor-lithgow","URL":"https://www.biorxiv.org/content/10.1101/2021.05.11.443681v1.abstract","Tags":["Phage biology","Research paper"],"Publication date":"May, 2021","Authors":"Wai Hoe Chin, Ciaren Kett, Oren Cooper, Deike Müseler, Yaqi Zhang, Rebecca Bamert, Ruzeen Patwa, Laura C. Woods, Citsabehsan Devendran, Joe Tiralongo, Trevor Lithgow, Mike J. McDonald, Adrian Neild, Jeremy J. Barr","Name":"Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis","First author":"Wai Hoe Chin"},{"id":"7d1e34eb-f781-47be-834e-4538d09e4bf1","format":{"copied_from_pointer":{"id":"db009381-46bc-4117-b4e8-4a949fbd40b9","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["JAC Antimicrobial Resistance"],"Profiles":"steven-tong","URL":"https://academic.oup.com/jacamr/article/3/3/dlab127/6352574?login=true","Tags":["Antibiotic resistance","Uropathogens"],"Publication date":"September, 2021","Authors":"Will Cuningham, Shalinie Perera, Sonali Coulter, Graeme R Nimmo, Trent Yarwood, Steven Y C Tong, Teresa M Wozniak","Name":"Antibiotic resistance in uropathogens across northern Australia 2007–20 and impact on treatment guidelines","First author":"Will Cuningham"},{"id":"82933f80-4e82-454a-b53a-1f52ae5c4bff","format":{"copied_from_pointer":{"id":"bb70d03f-cb50-4c1e-b8ba-6a2168fecf7b","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Current Opinions in Biotechnology"],"Profiles":"ruby-lin,jessica-sacher,jan-zheng","URL":"https://www.sciencedirect.com/science/article/abs/pii/S0958166920302020","Tags":["Phage biobank","Opinion paper"],"Publication date":"April, 2021","Authors":"Ruby CY Lin, Jessica C Sacher, Pieter-Jan Ceyssens, Jan Zheng, Ali Khalid, Jonathan R Iredell, The Australian Phage Biobanking Network.","Name":"Phage Biobank: Present Challenges and Future Perspectives","First author":"Ruby CY Lin"},{"id":"3b896421-b2fb-47e6-be67-dd0859f312a3","format":{"copied_from_pointer":{"id":"85eb8acd-1e3d-43a1-86db-fa36f6dd637e","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Research Square | Pre-print"],"Profiles":"ruby-lin,jon-iredell","URL":"https://assets.researchsquare.com/files/rs-110673/v1/0380f83a-2dc7-43b2-bc80-eaed366cb55c.pdf?c=1631861533","Tags":["Pediatrics","Phage Therapy","Clinical trial","Research paper"],"Publication date":"November, 2020","Authors":"Ameneh Khatami, Ruby Lin, Aleksandra Petrovic-Fabijan, Sivan Alkalay-Oren, Sulaiman Almuzam, Philip Britton, Michael Brownstein, Quang Dao, Joseph Fackler, Ronen Hazan, Bri’Anna Horne, Ran Nir-Paz, Jonathan Iredell","Name":"Therapeutic monitoring of the host-bacterium-phage interaction in a child","First author":"Ameneh Khatami"},{"id":"205d3c0c-969d-4e6f-8372-1e7714761039","format":{"copied_from_pointer":{"id":"c2d8e488-4ddf-4a55-bbad-bd1bae66a200","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Microbiology Australia"],"Profiles":"ruby-lin","URL":"https://www.publish.csiro.au/ma/pdf/MA19005","Tags":["Phage Therapy","Research paper"],"Publication date":"March, 2019","Authors":"Carola Venturini, Aleksandra Petrovic Fabjian and Ruby CY Lin","Name":"Bacteriophage therapy for severe infections","First author":"Carola Venturini"},{"id":"3084dc16-ed07-4717-b432-db5229e0de9b","format":{"copied_from_pointer":{"id":"a1b0539e-5391-4237-84b3-79caa7d8ad20","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["ASM Journal: mSystems"],"Profiles":"jeremy-barr,trevor-lithgow","URL":"https://journals.asm.org/doi/full/10.1128/mSystems.00242-21","Tags":["Research paper","Phage Machine-Learning","Phage biology"],"Publication date":"May, 2021","Authors":"Tze Y. Thung, Murray E. White, Wei Dai, Jonathan J. Wilksch, Rebecca S. Bamert, Andrea Rocker, Christopher J. Stubenrauch, Daniel Williams, Cheng Huang, Ralf Schittelhelm, Jeremy J. Barr, Eleanor Jameson, Sheena McGowan, Yanju Zhang, Jiawei Wang, Rhys A. Dunstan, and Trevor Lithgow","Name":"Component Parts of Bacteriophage Virions Accurately Defined by a Machine-Learning Approach Built on Evolutionary Features","First author":"Tze Y. Thung"},{"id":"de84d7a0-bd01-4c8c-96ec-61a3f988b1cc","format":{"copied_from_pointer":{"id":"81d3d0b3-c281-44c7-82fa-f4cd02d8c7e5","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Annals of Internal Medicine"],"Profiles":"steven-tong","URL":"https://www.acpjournals.org/doi/abs/10.7326/M21-1491","Tags":["Staphylococcus","MRSA","Clinical"],"Publication date":"May, 2021","Authors":"Steven Y.C. Tong","Name":"Annals for Hospitalists Inpatient Notes - Clinical Pearls—Methicillin-Resistant Staphylococcus aureus Bacteremia","First author":"Steven Y.C. Tong"},{"id":"4c1aa1e4-5875-409b-ba98-216ed9826cde","format":{"copied_from_pointer":{"id":"88fae20e-6cb5-45b1-b186-b361b30a1661","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["BMC Microbiology"],"Profiles":"morgyn-warner","URL":"https://link.springer.com/article/10.1186/s12866-020-01891-8","Tags":["Phage Therapy","Staphylococcus","Animal model"],"Publication date":"July, 2020","Authors":"Legesse Garedew Kifelew, Morgyn S. Warner, Sandra Morales, Lewis Vaughan, Richard Woodman, Robert Fitridge, James G. Mitchell & Peter Speck","Name":"Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus","First author":"Legesse Garedew Kifelew"},{"id":"b0825bf3-2797-4e2e-b233-7a505d7ae717","format":{"copied_from_pointer":{"id":"7bbf3266-38a8-4f92-bbef-41fa94df1be4","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["MDPI: Viruses"],"Profiles":"stephen-stick,anthony-kicic","URL":"https://www.mdpi.com/1999-4915/13/9/1809","Tags":["Review paper","Respiratory Tract infections","Phage Therapy"],"Publication date":"September, 2021","Authors":"Joshua J. Iszatt, Alexander N. Larcombe, Hak-Kim Chan, Stephen M. Stick, Luke W. Garratt and Anthony Kicic.","Name":"Phage Therapy for Multi-Drug Resistant Respiratory Tract Infections","First author":"Joshua J. Iszatt"},{"id":"da278674-986c-4b72-a559-45f7e2d41789","format":{"copied_from_pointer":{"id":"7ea133e9-5ece-40d4-8082-6a08df8389d2","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["EMBO Molecular Medicine"],"Profiles":"ameneh-khatami,ruby-lin,jon-iredell","URL":"https://www.embopress.org/doi/full/10.15252/emmm.202113936","Tags":["Clinical trial","Pediatrics","Immune response","Phage Therapy"],"Publication date":"August, 2021","Authors":"Ameneh Khatami, Ruby C Y Lin, Aleksandra Petrovic-Fabijan, Sivan Alkalay-Oren, Sulaiman Almuzam, Philip N Britton, Michael J Brownstein, Quang Dao, Joe Fackler, Ronen Hazan, Bri’Anna Horne, Ran Nir-Paz,\nJonathan R Iredell","Name":"Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child","First author":"Ameneh Khatami"},{"id":"ad16047b-db20-4f8a-b082-de3eece67abb","format":{"copied_from_pointer":{"id":"5f5c618b-9192-4490-974c-2f45e0f2170a","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["International Journal of Infectious Diseases"],"Profiles":"ruby-lin,jon-iredell","URL":"https://www.ijidonline.com/article/S1201-9712(20)31081-X/fulltext","Tags":["Phage Virulence","Antibiotic synergy","Research paper"],"Publication date":"December, 2020","Authors":"A. 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Warner, Sandra Morales, Nicky Thomas, David L. Gordon, James G. Mitchell, and Peter G. 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Dunstan, Rebecca S. Bamert, Matthew J. Belousoff, Francesca L. Short, Christopher K. Barlow, Derek J. Pickard, Jonathan J. Wilksch, Ralf B. Schittenhelm, Richard A. Strugnell, Gordon Dougan, and Trevor Lithgow","Name":"Mechanistic Insights into the Capsule-Targeting Depolymerase from a Klebsiella pneumoniae Bacteriophage","First author":"Rhys A. Dunstan"},{"id":"fdd33411-daa3-41e3-bbb7-16424bc0ce81","format":{"copied_from_pointer":{"id":"56b9f07d-e784-4456-97e1-cf617f54dee3","table":"block","spaceId":"a8000652-f2c8-4adc-9353-cd51c033cc1f"}},"Published":true,"Type":"Publication","Journal":["Clinical Microbiology & Infection"],"Profiles":"steven-tong","URL":"https://www.sciencedirect.com/science/article/abs/pii/S1198743X21006157","Tags":["Antibiotic resistance","Staphylococcus","MRSA"],"Publication date":"October, 2021","Authors":"Joshua S. Davis, Neta Petersiel, Steven YC. 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Phage therapy changed the life of this brave Sydney teen, after years of treatment for a stubborn infection. Read more 👇 @SCHNkids @WestSydHealth @WestmeadInst @PhageAustralia #kidsresearch #phagetherapy #phage #cysticfibrosis https://t.co/PMxVPT2B6f
— Kids Research (@kids_research) July 15, 2022

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Excited to have received funding to create a phage production facility for those severely ill. @telethonkids @WalyanCentre, @PhageAustralia

Reading: Future Health Research and Innovation Fund - Innovation Seed Fund grant recipients https://t.co/WytRgGSOg9 #Future
— Anthony Kicic (@DrAnthonyKicic) July 5, 2022

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Congratulations to @jcarapetis @telethonkids Executive Director & Winthrop Professor at @uwanews - elected as a new Fellow of the prestigious @Science_Academy in recognition of his pioneering, paradigm-shifting expertise in infectious diseases

READ: https://t.co/vZvLYMgEMs pic.twitter.com/iLRyEeh62k
— UWA Research (@UWAresearch) May 26, 2022

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CI Khatami’s research career spans 3 continents with a wide network of international collaborators. This started with clinical leadership of vaccine trials carried out with the Oxford Vaccine Group at the University of Oxford, under the supervision of Sir Andrew Pollard. Subsequent experience includes time at New York University, investigating Group B Streptococcus colonisation in women. Since returning to Sydney in 2019 CI Khatami has developed extensive collaborations with respiratory medicine specialists throughout Australia, with a focus on antimicrobial therapies in children with cystic fibrosis (CF).\nCI Khatami is the Phage Therapy Content Expert for the Sydney Children’s Hospitals Network (SCHN) Advanced Therapeutics Steering Committee and was the first clinician in Australia to treat a paediatric patient with intravenous phage therapy (October 2019) for a highly resistant _Pseudomonas aeruginosa_ bone infection with support from CI Iredell. The publication of this case was featured on the cover of EMBO Mol Med in 2021 (), with CI Khatami subsequently interviewed for a podcast on the publication . CI Khatami has also overseen the treatment of additional paediatric patients using phages against _Mycobacterium abscessus_ (including the first use of a genetically modified phage in Australia). \n**Current Phage Therapy Research and Funding**\nCI Khatami has been awarded an NHMRC Investigator Grant at Emerging Leadership 1 level for a program of research to develop phage therapy as a novel solution for difficult to treat infection in children. Other recent awards include a Conquer CF, Innovation Grant from Cystic Fibrosis Australia, a Research Establishment Fellowship from the Royal Australasian College of Physicians and the inaugural Research Award from the Australasian Society for Infectious Diseases all linked to a research project to develop effective phage cocktails to eradicate early infection with _P. aeruginosa_ and _Staphylococcus aureus_ from children with CF. CI Khatami has also been awarded a PhD scholarship by the NSW OHMR to conduct research on ohage therapy for rapidly growing mycobacteria. \nBased on experience to date of treating patients, CI Khatami has also led the development of a standardised phage therapy clinical trial protocol, endorsed nationally by adult and paediatric infectious diseases specialists (STAMP ).\n","Slug::Auto":"ameneh-khatami","recordId":"recT6KSbDpQqA4pTV","Profile Image URL":"https://dl.phage.directory/.attachments/4ccd572f4df81350cafdfc1aa62f95b5/87074b19/ProfilephotoAmeneh.jpg","Editable Form Link":{"label":"Form Edit 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Lead the SNAP and ASCOT clinical trials","Category":["Chief Investigator"],"Name":"Steven Tong","Profile":[{"id":"attL5bj3pZUvhlP50","width":111,"height":111,"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/i_e9Oib7FudlJVudRoEXVQ/LSp1J5gJtft5hbqdzTxmDVGCbx1YuMLOhC6nuRwyAM3D0KYDOpXgA52GDydc6LQVAjdGD_MdBHCIQu5MFCKemzDIv2MMJqpDjXNkizo2QOo/qtIM2V5tLuor13GVK5QT_n42r_CLk4qD9oYmPHt3CBQ","filename":"S.Tong_Deepetched.png","size":16412,"type":"image/png","thumbnails":{"small":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/WIqjFgY7kNG4FrJsHNaNAQ/d8faC_ziHxJdwGIxszNzBIzwpTD3GICpJyPs6-JuR0juT9J--XeEDIvIFlBf9EsUBXaaEqOhFZYePnwaC3tSnA/i19jjI0ZLx1qp0Q_tLssDfjGHuc_Mij_qtq9tlzxkxk","width":36,"height":36},"large":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/d0sP8sM4HSM56KsWwZp6rA/nqejeqhrp-HoIGO0JmLfEM57M9EgGFzvdxPHp-7sbGCXUUzQko0djxv68uD3SBgshOPJ_JZKqqpSZShLn9k5vg/_tcMgwX3DxWPjRBbhaGvDD1OfKRxO2wyweLhWT76qYA","width":111,"height":111},"full":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/_qx_VR97ajbrdzigjsbvTA/rsFyc_O1Q1lb7kzdcMo0lYvDAhbGX0oeRuJL9-HqsujjVoXZDSHaCYlWOT9OgFqKMsMwauOZGSfdK6QWqb2ciw/oYXITLCbEGxa7BXpQt69-Cza9gkE0SNlMWwUuoGfnOM","width":3000,"height":3000}}}],"Linked Profiles":["recgy09hjJvHkWWb1","recI5mdxQBKuPspzH","rectvHOqyYmRE4bMN","recrsa1LLDca0FtY5"],"Position":"Infectious diseases clinician scientist","Title":"Professor","Status":"Published","Last name":"Tong","Slug":"steven-tong","Twitter":"https://twitter.com/syctong","Location":"Victoria","Description":"Prof Steven Tong is an infectious diseases clinician at the Royal Melbourne Hospital (RMH) at the Doherty Institute. He leads the _Staphylococcus aureus_ Network Adaptive Platform trial, an NHMRC funded global adaptive platform trial (GNT #1184238, CIA, 2020-2024, $4.95M; also NZ HRC, Canadian IHR grants for additional $2M) and the Australasian COVID-19 Trial (ASCOT), which has been funded through philanthropy, and has recruited >1,600 participants in Australia, NZ, India, and Nepal. He chairs: the Australasian Society for Infectious Diseases Clinical Research Network; the Translational and Clinical Research discipline at the Doherty Institute; and the Melbourne Academic Centre of Health Infection subcommittee.\nProf Tong has completed clinical trials and other complex projects including CAMERA2, the largest RCT for MRSA bloodstream infections (JAMA 2020). His involvement in REMAP-CAP for COVID has further built capacity for adaptive clinical trials in infectious diseases. He has given invited talks at major international infectious diseases conferences on adaptive platform trials (ECCMID 2019, American Society Microbiology 2019).\nHis work has also led to the discovery and naming of two new staphylococcal species and a novel genotype of Hepatitis B.\n","Slug::Auto":"steven-tong","recordId":"recYUGtop7CT6e9zY","Profile Image URL":"https://dl.phage.directory/.attachments/db5e23fd83a71937860c53f7f8bf15a0/13459047/S.Tong_Deepetched.png","Editable Form Link":{"label":"Form Edit 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He moved to the US as a PostDoc, first at the University of Pennsylvania in Philadelphia studying enterotoxigenic _E. coli_, and then at the University of Illinois, Urbana-Champaign studying the genomics and pathogenesis of _Salmonella_, work that he continued as an Assistant Professor at the University of Tennessee Health Sciences Center in Memphis, TN._ _Working with Argonne National Labs and the Fellowship for the Interpretation of Genomes (FIG) he developed the RAST and MG-RAST systems for bacterial genome and metagenome annotation.\nIn 2006, Rob took a position in the Departments of Computer Science and Biology at San Diego State University, and his work there led to breakthroughs in our understanding of how viruses interact with their hosts, and how viruses from around the world carry important genetic information. 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His major interest is in the field of Antimicrobial Resistance (AMR) where he is ranked number four in the world ([expertscape.com](https://expertscape.com/)).\n","Slug::Auto":"david-paterson","recordId":"recue5Ff118exd6Ek","Profile Image URL":"https://dl.phage.directory/.attachments/2023d1b6a393d5db21923e8fc5b088a6/5da1197d/D.Paterson.png","Editable Form Link":{"label":"Form Edit 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Heath","Profile":[{"id":"attssLkdYaOBw8vr6","width":111,"height":111,"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/dALQovxs2oPbck6f_8RABQ/Jb6fU8WdKPIK5dcvQ_EkOF8DHAC_bNfaemgLr5rl89gONnVSottrwa_irZxw_C3a_OX-rtJcDcTQY-fM-QMZbwZyACXaOTz3HxnFG5wVimw/v-SRu0jQkaUNS-vf1IlvPR_esDquqq65WM5i78Tluvk","filename":"Heath_CH.png","size":18847,"type":"image/png","thumbnails":{"small":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/wWnElECsr59iNVoFFHtq3A/xkWNFtNowtB46hLzsIDyLQl4M92RpF1DdBhM7poRc-bTzWtXPPy52m4GhjLVUv1HanbywEwXeE0HmFBD3wxgoQ/MH2Ya3WNLsAe5I5jP3Cm_4lmLTIAEC5e3d875aaJHmc","width":36,"height":36},"large":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/fvgvPYc0ds1y1Y3hWCuqhA/YafnBmGih1rhL9n0foKNuxUWOxZeT0KchrndbKaJ5Q_P8fDBjsFlChGBf5hV-cQw76w5JTu3qMnWTEEjQ6E_7g/LI-MWGFzufkXhiUgURHnHUUIpSYHi7lsFPJKdWhxusA","width":111,"height":111},"full":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/6QoDk88OPr3wEMU73RtJbQ/XsCOI5x9nUTelZGUsQXHi4ChqsNixgvEGunPzllW0p5hVJXb0mMw8VnoftK_ar1aEfqU1vmD5zVFTzksXVvnRg/WcItG8fdHuwk9kh4gpqlkvd7lQuwZ5MT7ZygECzZ72c","width":3000,"height":3000}}}],"Linked 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He has extensive experience with expertise in clinical infectious diseases and in diagnostic laboratory microbiology. Chris has active research interests in infections in the immunocompromised host, clinical and laboratory mycology, hospital-acquired infections and control of MRO’s, antimicrobial stewardship, contemporary diagnostics involving innovative technologies, microbial genomics and phylogenetics, and novel antimicrobials for emerging drug resistance – including bacteriophages. Dr Heath is an adjunct Clinical Associate Professor of Medicine at the University of WA.\n","Slug::Auto":"christopher-heath","recordId":"recXky3XqIM93oWNa","Profile Image URL":"https://dl.phage.directory/.attachments/c26caa50926a1917bf4e68b2928a4e6f/6850d2b3/Heath_CH.png","Editable Form Link":{"label":"Form Edit URL","url":"https://airtable.com/shr2X0cC6xAfHn4EB?prefill_recordId=recXky3XqIM93oWNa&hide_recordId=true&prefill_Title=Associate%20Professor&prefill_PostTitle=&prefill_Name=Christopher%20Heath&prefill_Location=WA&prefill_Short%20Description=Infectious%20Diseases%20Physician%20%26%20Clinical%20Mictobiologist%20at%20Royal%20Perth%20Hospital&prefill_Description=Dr%20Heath%20is%20an%20Infectious%20Diseases%20Physician%20%26%20Clinical%20Microbiologist%20%28PathWest%20Laboratory%20Medicine%29%20at%20both%20Fiona%20Stanley%20Hospital%20%28FSH%29%20%26%20Royal%20Perth%20Hospital%20%28RPH%29%20in%20Perth%2C%20WA.%0ADr%20Heath%20was%20the%20inaugural%20Head%20of%20Infectious%20Diseases%20at%20RPH%20from%201997%20until%202017.%20He%20has%20extensive%20experience%20with%20expertise%20in%20clinical%20infectious%20diseases%20and%20in%20diagnostic%20laboratory%20microbiology.%20Chris%20has%20active%20research%20interests%20in%20infections%20in%20the%20immunocompromised%20host%2C%20clinical%20and%20laboratory%20mycology%2C%20hospital-acquired%20infections%20and%20control%20of%20MRO%E2%80%99s%2C%20antimicrobial%20stewardship%2C%20contemporary%20diagnostics%20involving%20innovative%20technologies%2C%20microbial%20genomics%20and%20phylogenetics%2C%20and%20novel%20antimicrobials%20for%20emerging%20drug%20resistance%20%E2%80%93%20including%20bacteriophages.%20Dr%20Heath%20is%20an%20adjunct%20Clinical%20Associate%20Professor%20of%20Medicine%20at%20the%20University%20of%20WA.&prefill_Category=Chief%20Investigator&prefill_ProfileImageURL=https%3A%2F%2Fdl.phage.directory%2F.attachments%2Fc26caa50926a1917bf4e68b2928a4e6f%2F6850d2b3%2FHeath_CH.png&prefill_Linked%20Profiles=Royal%20Perth%20Hospital&prefill_Affiliation=&prefill_Position=Infectious%20Diseases%20Physician%20%26%20Clinical%20Microbiologist&prefill_Slug=christopher-heath&hide_Slug=true&prefill_Website=https%3A%2F%2Fwww.ecmm.info%2Ffecmm%2Ffellows%2Fheath-christopher%2F&prefill_Linkedin=https%3A%2F%2Fwww.linkedin.com%2Fin%2Fchristopher-heath-71674993%2F%3ForiginalSubdomain%3Dau&prefill_Twitter="},"Form Link":"https://airtable.com/embed/shr2X0cC6xAfHn4EB?prefill_recordId=recXky3XqIM93oWNa&hide_recordId=true&prefill_Title=Associate%20Professor&prefill_PostTitle=&prefill_Name=Christopher%20Heath&prefill_Location=WA&prefill_Short%20Description=Infectious%20Diseases%20Physician%20%26%20Clinical%20Mictobiologist%20at%20Royal%20Perth%20Hospital&prefill_Description=Dr%20Heath%20is%20an%20Infectious%20Diseases%20Physician%20%26%20Clinical%20Microbiologist%20%28PathWest%20Laboratory%20Medicine%29%20at%20both%20Fiona%20Stanley%20Hospital%20%28FSH%29%20%26%20Royal%20Perth%20Hospital%20%28RPH%29%20in%20Perth%2C%20WA.%0ADr%20Heath%20was%20the%20inaugural%20Head%20of%20Infectious%20Diseases%20at%20RPH%20from%201997%20until%202017.%20He%20has%20extensive%20experience%20with%20expertise%20in%20clinical%20infectious%20diseases%20and%20in%20diagnostic%20laboratory%20microbiology.%20Chris%20has%20active%20research%20interests%20in%20infections%20in%20the%20immunocompromised%20host%2C%20clinical%20and%20laboratory%20mycology%2C%20hospital-acquired%20infections%20and%20control%20of%20MRO%E2%80%99s%2C%20antimicrobial%20stewardship%2C%20contemporary%20diagnostics%20involving%20innovative%20technologies%2C%20microbial%20genomics%20and%20phylogenetics%2C%20and%20novel%20antimicrobials%20for%20emerging%20drug%20resistance%20%E2%80%93%20including%20bacteriophages.%20Dr%20Heath%20is%20an%20adjunct%20Clinical%20Associate%20Professor%20of%20Medicine%20at%20the%20University%20of%20WA.&prefill_Category=Chief%20Investigator&prefill_ProfileImageURL=https%3A%2F%2Fdl.phage.directory%2F.attachments%2Fc26caa50926a1917bf4e68b2928a4e6f%2F6850d2b3%2FHeath_CH.png&prefill_Linked%20Profiles=Royal%20Perth%20Hospital&prefill_Affiliation=&prefill_Position=Infectious%20Diseases%20Physician%20%26%20Clinical%20Microbiologist&prefill_Slug=christopher-heath&hide_Slug=true&prefill_Website=https%3A%2F%2Fwww.ecmm.info%2Ffecmm%2Ffellows%2Fheath-christopher%2F&prefill_Linkedin=https%3A%2F%2Fwww.linkedin.com%2Fin%2Fchristopher-heath-71674993%2F%3ForiginalSubdomain%3Dau&prefill_Twitter=","record_id":"recXky3XqIM93oWNa"},{"Website":"https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/hien-duong.html","Linkedin":"linkedin.com/in/hien-duong-83a609b0 ","Short Description":"Dr Hien Duong senior lecturer in pharmaceutical sciences at the University of Sydney Pharmacy school. She is an expert in polymer chemistry, organic and inorganic/organic hybrid nanomaterials. She has established herself as a leader in using nanotechnology in the form of nanoparticles for biomedical application.","Category":["Chief Investigator"],"Name":"Hien Duong","Profile":[{"id":"attgDxTB8Y0bysqe5","width":300,"height":300,"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/kHNvptZIPABZISkl0BfLhw/k6pATgXuClCXdTy8LG9moY91tCmMzz4oOdYPQ6t_V_cEYmViXz_kY7BURnb-tSgFeBD9-90utMNu4nDdVDJEplounRGJPRj0jH_TUO6RWlU/fS3RSNsC8XTTTjp232esAjPNenP4vuU_pa01cDxq5Ug","filename":"profile photo Hien_1.jpg","size":31031,"type":"image/jpeg","thumbnails":{"small":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/Ld3R7ITf5LfwQHzpc_awgg/JXuZ3Vb5DhgJC1Awqf3BnConLrXXXQ6C3kiUuOnZSXVwC18Srgu-ydEal8aD2-QVT7q46s1bQ52ZZZ6F3g9YRg/gq_era9umxRAOtSzhSr6bO4MpS34Z0jrow1jvyrGHcI","width":36,"height":36},"large":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/JS0_c4N-PoaXw4bdVLkKbg/8ZZODJ1IqlNIa9AKCaOfg_ExxIRKHDKsgwxWPx46-5At5xx57Izr0Fl7_S8JvQvjhxEf8DSG_PMr7qKrDGOchQ/rsPx5ERZGBiLd0T1wKab09g6rtbUx1HF6FrocWqLgrQ","width":300,"height":300},"full":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/hp_tWQtyFv7lSBYETloP7w/gPf06733Mm31-zY9ZJ6Han4Fh8rrqZ9vdjZgQUp1WIdNk9ceuTGXsTVCYUJFhvTYsEeYVYsbqHQldnOYhupbmA/GXz76U_yblhcPcPxuzOhjUAyl-mbrIYCh76y0DU27ro","width":3000,"height":3000}}}],"Linked Profiles":["recrVq0k7wusEZKZS"],"Position":"Senior lecturer","Title":"Dr","Status":"Published","Last name":"Duong","Slug":"hien-duong","Location":"Sydney, NSW, or Australia","Description":"** **\nI was awarded my PhD in 2011 from the University of New South Wales. \n\n**RESEARCH OPPORTUNITIES**\n** **\n**i) A description of my role**\n\nAfter I finished my PhD in 2011, I commenced my postdoctoral academic career at the Australian Centre for NanoMedicine (established by UNSW in 2011) in the lab of Profs Tom Davis and Cyrille Boyer, both of whom are world experts in polymer science. There I developed several inorganic and organic nanomaterials with different functionalities that can undergo post-modification via highly efficient and orthogonal chemistry. I gained extensive experience in understanding the interface between nanotechnology and biomedical science.\n\nIn November 2014 I joined the Key Centre for Polymers and Colloids in the School of Chemistry at the University of Sydney, in the lab of A/Profs Brian Hawkett and Chiara Neto. This position was funded through an ARC Linkage grant with Dulux Australia. I worked on the development of Janus nanoparticles with multiple functionalities and complex architecture. These nanoparticles potentially have a wide range of uses, ranging from biomedical applications to the paint industry.\n\nIn May 2016 I joined the Institute for Biomedical Materials & Devices in the School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, as a Senior Research Fellow in the lab of Prof Dayong Jin. At UTS, I worked on multi-functional polymers to functionalise upconversion nanoparticles for use in diagnostic and therapeutic applications. I was part of the ARC Industry Transformation Research Hub for Integrated Devices for End-User Analysis at Low Levels (IDEAL Hub). \n\nIn February 2017 I took up my current position as lecturer in the School of Pharmacy at the University of Sydney. In this role, I have a typical load for a university-based researcher consisting of 40% teaching, 40% research and 20% administration. \n\nMy administration workload includes coordinating two units of study, being a representative of the School of Pharmacy on the University Executive Student Life Committee for one year and being involved in Pharmacy ECR activities. I hold a leadership role in the School including Sydney Pharmacy School Professionalism Committee.\n\nDespite my substantial non-research activities, I have been building a dynamic research environment with a fresh approach to the development of alternative therapies based on nano-enabled products. In recognition of my research leadership at USyd, I was appointed as leader of Antimicrobial Nanotechnologies theme in Safe-by-Design - Sustainable Nanotechnology, Sydney Nano Grand Challenge from 2019 to 2021. Recently, I was awarded Sydney Infectious Diseases Seed Funding (2022, $25,000) and Sydney Nano Kickstarter (2022, $50,000) to work on bacteriophage conjugates. I am one of the investigators who secured Stage 1 MRFF Frontiers funding for Phage Australia (A$1 million, 06/2021-06/2022) which is led by Prof Jonathan Iredell at the Westmead Institute for Medical Research. The application for MRFF Frontiers Stage 2 bid for $50M will be submitted in June 2022.\nI developed strong understanding of the needs of industry partners through collaborations with Dulux Australia (at USYD) and Minomic International Ltd (through the ARC IDEAL Hub at UTS). This also expanded my understanding of the requirements for business success. \n\n**ii) Research mentoring and facilities**\n** **\nAt the University of Sydney, I have benefited from both formal and informal mentoring by senior colleagues. Through the University’s Academic Planning & Development System, I have received excellent support and mentorship from Profs Mary Collins and Paul Groundwater at the School of Pharmacy. I also receive informal mentoring from other senior researchers within the School and throughout the University including Profs Andrew McLachlan (HoS), Wojciech Chrzanowski, Jonathan Iredell and Gregory Whitwell and senior researchers in the Australian Centre for Microscopy & Microanalysis (ACMM), Charles Perkins Centre (CPC) and Bosch Institute. Earlier in my career, I have received excellent mentorships from all my aforementioned postdoc supervisors.\n\nResearch facilities at the School of Pharmacy include a complete suite of state-of-the-art instruments for the characterization of nanomaterials, including vibrational spectroscopy, microscopy and microanalysis, and facilities for molecular characterization such as NMR, GPC, mass spectrometry, thermogravimetric analysis, differential scanning calorimetry. I have immediate access to instruments for the rapid and routine structural and physical characterization of surfaces required in this Discovery Project. \n\n**RESEARCH ACHIEVEMENTS AND CONTRIBUTIONS**\n** **\n**i) Prizes, honours and awards**\n** **\n 2017\n Early Career Development Fellowship, University of Sydney\n 2015\n Monash Engineering Women's Leadership Award\n 2011\n Runner-up prize for the oral presentation at the International Nanomedicine Conference \n 2009\n Postgraduate Research Student Scholarship\n 2007\n Endeavour Postgraduate Award (Australian Government merit-based scholarship) for a PhD Engineering program (2007-2011).\n 2003\n Australian Development Scholarship for a Masters Engineering program (2003-2005) at UNSW.\n\n **ii) Invited speaker addresses**\n\nI was invited to deliver a talk on innovative nanotechnology for biomedical applications at the 2016 Rural Innovation and Research Symposium, Coffs Harbour. I have given a number of invited departmental seminars as at Macquarie University, UNSW, the University of Sydney and the University of Queensland. I am invited as a Keynote Speaker for the 4th International Seminar on Pharmaceutical Science and Technology in Bandung, Indonesia on 27-28/10/2020.\n \n**iii) Research support income **\n_ _\n· _Ultra-high-performance microbalance, XPR2_, University of Sydney, Faculty of Pharmacy/Equipment Grant 2017.\n· _Novel 3-in-1 formulation for prostate cancer treatment_, India Development Fund (Chief Investigator, $20K, 2017-2018).\n· _Inhaled therapy for chronic lung infections using a “triple hits” nano-in-microparticle formulation_, Usyd-Chinese University of Hong Kong Partnership Collaboration Award (Chief Investigator, $20K, 2018-2019).\n· _Safe-by-Design - Sustainable Nanotechnology_, Sydney Nano Grand Challenge, (co-CI, $75K per year, 2019-2021).\n· _Phage Australia: Integrating Australian Phage Biobanking and therapeutic networks and Delivering Solutions for Antimicrobial Resistance_ (co-CI, $1M, 06/2021-06/2022).\n· _Phage-drug conjugate: solution for antimicrobial resistance, _Sydney ID Seed Funding_ _(Chief Investigator, $25K, 2022)._ _\n· _Bacteriophage nanorobots_, Sydney Nano Kickstarter (Chief Investigator, $50K, 2022)._ _\n· _Freeze Dryer with controllable drying shelf temperature and organic solvent compatibility, _2022 Provost’s Equipment_ _(co-CI, $102K, 2022).\n· _PAVONE –transformative, automated high throughput testing platform for nanomedicine, mechanopharmacology, mechanobiology, and precision, _2022 Provost’s Equipment_ _(co-CI, $217K, 2022).\n\n**iv) Commercial outcomes**\n** **\n1\\. Barraud, N, Boyer, C, and **Duong, HTT** “Anti-Biofilm Polymer”, filed 30 May 2014\n2\\. Vittorio, O, Kavallaris, M, Boyer, C, and **Duong, HTT** “Copper-dependent chemotherapeutics”, filed 30 May 2016.\n3\\. **Duong, H. T. T. T**.; Iredell, J. R.; Huang, H. “Phage-drug conjugate”, filed 29 November 2021.\n \n**v) Other professional activities**\n \nAs a sign of my strong national and international standing in my discipline, from 2011 to 2014, I was one of the team leaders of the organizing committee International Nanomedicine Conference which is held annually in Sydney. In February 2016 I was involved in organizing the 30th Australian Colloid and Surface Science Student Conference in Kiola, NSW. I was invited as co-chair in Career Development Symposium session in the eighth International Conference on Nanoscience and Nanotechnology (ICONN 2020) which is the largest biennial Australian conference series in the field of nanoscience. I am invited as a Keynote Speaker for the 4th International Seminar on Pharmaceutical Science and Technology in Bandung, Indonesia on 27-28/10/2020. I am a regular referee for high-impact scientific journals. \n\n**vi) Advancement of knowledge in my field and relevance of my achievements to this proposal**\n** **\nMy research is multidisciplinary, focusing on new concepts and ideas to engineer novel materials and devices at nanoscale. As a polymer chemist I have developed a broad range of expertise in the application of nanotechnology in biotechnology. I have made a significant contribution to the field of nanotechnology for biomedical applications, which is likely to have a high impact on improved therapy of life-threatening diseases including biofilm-related infectious diseases. I have a strong international reputation for research in nanomedicine, as demonstrated by my publication record (45 peer-reviewed publications, three patents, one book chapter and 8 fully refereed conference proceedings). My leadership is evident by the number of publications with me as first and corresponding authors. \n\n\n","Slug::Auto":"hien-duong","recordId":"rec6yfvVsLeKyo5Uo","Profile Image URL":"https://dl.phage.directory/.attachments/13feab50e64b5be22f9a23f1d2b9d89b/a24970fe/profilephotoHien_1.jpg","Editable Form Link":{"label":"Form Edit 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Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection; Cell Reports Medicine (2021), https://doi.org/10.1016/j.xcrm.2021.100228.\n3\\. Shiel E, Miyakis S, Tennant E, Fernando S, Kizny-Gordon A, Koh B, Findlay M, Garnham K, Pilli S, Segboer H, Tallon J, Kao J, Miller A, Shore T, Maher R, Telford M, Barclay K, Harris B, Newcombe J, **Hudson B**, Figtree M. Clinical Characteristics and Outcomes of COVID-19 in a low-prevalence, well-resourced setting _Internal Medicine Journal_. 2021 Jul 06. [Journal Article] [2021/07/06 13:29].\n4\\. Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection. Abayasingam A, Balachandran H, Agapiou D, Hammoud M, Rodrigo C, Keoshkerian E, Li H, Brasher NA, Christ D, Rouet R, Burnet D, Grubor-Bauk B, Rawlinson W, Turville S, Aggarwal A, Stella AO, Fichter C, Brilot F, Mina M, Post JJ, **Hudson B**, Gilroy N, Dwyer D, Sasson SC, Tea F, Pilli D, Kelleher A, Tedla N, Lloyd AR, Martinello M, Bull RA, COSIN Study Group. _Cell_ _Reports_ _Medicine_. 2(4):100228, 2021 Apr 20. [Journal Article] [2021/03/22 08:31].\n5\\. Beukers AG, Newton P, Hudson B, Ross K, Gottlieb T, O'Sullivan M, Daley DA, Pang S, Coombs GW, van Hal SJ.A multicentre outbreak of ST45 MRSA containing deletions in the spa gene in New South Wales, Australia. _Journal of Antimicrobial Chemotherapy_. 75(5):1112-1116, 2020 05 01. [Journal Article. Multicenter Study] [2020/02/05 06:00].\n6\\. Contamination of the Surgical Field with Propionibacterium acnes in Primary Shoulder Arthroplasty. Falconer TM, Baba M, Kruse LM, Dorrestijn O, Donaldson MJ, Smith MM, Figtree MC, **Hudson** **BJ**, Cass B, Young AA. _Journal of Bone & Joint Surgery_ - American Volume. 98(20):1722-1728, 2016 Oct 19. [Journal Article] [2016/11/22 06:00].\n7\\. Identification of a Novel Equine Papillomavirus in Semen from a Thoroughbred Stallion with a Penile Lesion. Li CX, Chang WS, Mitsakos K, Rodger J, Holmes EC, **Hudson BJ** _Viruses_. 11(8), 2019 08 04. [Journal Article. Research Support, Non-U.S. Gov't] [2019/08/07 06:00] UI: 31382657.\n**_Research Impact and Support: _**In 2020, A/Prof Hudson has established the first ever Infectious Diseases Clinical Research Unit at Royal North Shore Hospital. This Unit has attracted over $1.25 million in funding for investigation of patients with tickborne disease, using cutting edge genomic and biomarker techniques. Since onset of the SARS-2-CoV/COVID-19 pandemic, the RNSH Microbiology laboratory is consistently in the top 4 government laboratories in NSW by volume for SARS-2-CoV PCR tests performed. A/Prof Hudson is the laboratory expert member of NSLHD COVID-19 Executive and RNSH COVID-19 Executive and co-chair of NSLHD COVID-19 Research Committee, the major steering committees for NSLHD and RNSH during the pandemic. \n1\\. F2G Study (2021-Current): A Phase III, adjudicator-blinded, randomised study to evaluate the efficacy and safety of treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with invasive fungal disease (IFD) caused by Aspergillus species Role: Global Clinical Trials Program Manager and NSWLHD-NSWHP North Coordinating Principal Investigator.\n2\\. ARMATA AP-SA02 (2021-Current): Phase 1b/2a, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Escalation Study of the Safety, Tolerability, and Efficacy of Intravenous AP-SA02 as an Adjunct to Best Available Antibiotic Therapy Compared to Best Available Antibiotic Therapy Alone for the Treatment of Adults With Bacteremia Due to Staphylococcus aureus Role: Global Clinical Trials Program Manager and NSLHD-NSWHP North Principal Investigator.\n3\\. Oncology Study (2021-Current): Immune response to COVID vaccination in patients with malignancy. Multicentre Clinical Trials NSLHD-NSWHP North Principal Coordinator.\n4\\. COVID & HCW (2021-2021): Impacts of COVID-19 on NSW Health Care Workers. Clinical Trials Principal Coordinator.\n5\\. Prevalence of Asymptomatic SARS-Cov-2 Infection in Elective Surgical Patients in Australia. Multicentre study (2020-2021). Clinical Trials NSWHP North Principal Investigator.\n6\\. COVID-19 & Biomarker study (2021-2022): Identification of new biomarkers for severity, disease progression and response to treatment for COVID-19. Multicentre Clinical Trials NSWHP North Principal Coordinator.\n7\\. Australasian COVID-19 Trial (ASCOT) ADAptive Platform Trial: Multicentre Clinical Trials NSLHD-NSWHP Principal Investigator.\n8\\. COSIN Study (2020-2022) - Snow Medical Research Foundation: A national biobank of highly characterised samples from symptomatic and asymptomatic COVID-19 positive individuals, jointly led by a national consortium of researchers from the University of Melbourne, UNSW and The University of Sydney. NSLHD-NSWHP North Principal Investigator.\n9\\. Clinical and Laboratory Findings in Patients with Tickborne Diseases (2021-2026) - Snow Medical Research Foundation - Vectorborne Disease Clinical Research Centre Royal North Shore Hospital Northern Sydney Local Health District, University of Sydney, Macquarie University.\n10\\. Single target LOW Positive for SARS-CoV-2 diagnosis (LOW-POS) (2020-Current). Principal Investigator.\n11\\. Improving diagnostics for detection of enterovirus outbreaks by collection and PCR of residual enterovirus-positive samples (2019-2026). NSLHD-NSWHP North Principal Investigator.\n12\\. Pathogen Discovery (2020-Ongoing) – SREI: Centre for Pathogen Discovery, Holmes E, Shi M, Eden J, Sintchenko V, Lo N, Barrs V, Beatty J, Hudson B, Rose K, Rockett R, DVC Research/Sydney Research Excellence Initiative 2020.\n13\\. Next Generation Sequencing for Detection of Tickborne Pathogens in Australia (2018-2021) – NHMRC: Using Metagenomics to Determine the Causative Agents of Tick-Borne Disease in Australia, Holmes E, Bunce M, Hudson B, Lo N, Hansen A, National Health and Medical Research Council (NHMRC)/Project Grants.NSLHD-NSWHP North Principal Investigator.\n**_National and International Scientific Recognition:_** A/Prof Hudson is the founding chair of the Travel Health Advisory Group (THAG) a peak body affiliated with the Australian College of Tropical Medicine that promotes safe and healthy travel to the community as well as sponsoring research studies in travel medicine and health. For over 20 years, A/Prof Hudson has lectured annually as a guest professor at the travel medicine block in the Master of Public Health program at James Cook University, Townsville. For over 10 years, he has also been an invited speaker at the Global Health Program at Sydney University and the Master of Infection and Immunology Program at Westmead Hospital/ICPMR. A/Prof Hudson has been a topic editor for Frontiers in Microbiology and has peer reviewed a number of papers for local and international journals.\n\n\n\n\n\n\n\n","Slug::Auto":"bernard-hudson","recordId":"recrcJmtgkRyi5Z6t","Profile Image URL":"https://dl.phage.directory/.attachments/30e7a1446560da976d4c764c01118e9b/b29c5808/BJH3.PNG","Editable Form Link":{"label":"Form Edit 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Community program.","Category":["Partner Investigator"],"Name":"Amith 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Profiles":["recrVq0k7wusEZKZS","recx9glxlGq9WHpzy","recZxKYDdk1HqRfCF","recL7d4MMsRrym7NK","rec8gNmZEjySyHPBx"],"Position":"ID clinician","Affiliation":"WSLHD, Sydney Uni","Title":"Dr","Status":"Published","Last name":"Shetty","Slug":"amith-shetty","Twitter":"https://twitter.com/Docshetty","Location":"Sydney NSW Australia","Description":"# Dr Amith Shetty MBBS, FACEM, PhD\nMob: +61402453061 email: amith.shetty@health.nsw.gov.au\n**Goals**\nThe creation of an effective learning healthcare system through collaboration, sound leadership and integration of knowledge streams capable of delivering safe and high-quality better value care with improved patient experiences and outcomes.\n# Employment\n## Current position\n**_ _**\n**_Clinical Director, Patient Experience and System Performance Support division, NSW Ministry of health (Since July 2019 to now)_**\n## Current role and projects\n \nClinical Lead, COVID-19 Care in the community NSW health and Clinical lead, SIA COVID-19 Capacity Collaborative NSW health modelling group, Member Critical Intelligence Unit and Clinical Council for NSW COVID-19 response teams\nChair, COVID-19 care in the home Community of practice NSW Health\nClinical lead, COVID-19 community risk of deterioration live patient tracker\n## Immediate past appointments\n**_ _**\n**Director, **Hospital in the Home service, Western Sydney Local Health District since September 2016-19\n**Clinical Director, **eHealth NSW 2017-19, Electronic Transitions of care project (Medication Safety), Clinical analytics and Shared learning programs, Real-time risk trigger monitoring program \n**Staff Specialist**, Westmead Hospital Emergency department, Western Sydney Local health district since February 2012\n \n**Honorary Research Fellow**, NHMRC centre for research excellence in critical infection, Westmead Institute for Medical Research (WIMR) since June 2014\n \n**Director**, Westmead Emergency Medical Research unit, Westmead Hospital, Emergency department since January 2014\n \n**Clinical Senior Lecturer**, Sydney Medical School, University of Sydney, Westmead Campus since February 2012\n## Key Achievements (last 5 years)\n### · NSW Ministry of Health\no Clinical director for division comprising of System performance support, System purchasing, performance management and system information and analytics\no Clinical guidance and leadership on key interventions/ programs/ models of care at NSW health\n### · eHealth NSW\no Clinically led the proof of concept of the first electronic medications interoperability project to aid transitions of care and information sharing between disparate ward and ICU clinical information systems\no Clinically leading the first of it’s kind Internet of Things (IoT) project for device integration in NSW with eHealth NSW, NSW pathology and WSLHD\no Clinically leading and implemented the first of its kind algorithm-based risk-harm prediction and reporting system pilot in NSW hospitals\n### · NSW health\no Currently coordinating and designing system level changes needed to deliver on the recent NSW Premier’s priorities for health\no Developing and co-designing novel models of care for care of acute non- emergent patients in NSW hospitals in current role\no State-wide emergency medicine clinical lead for the Sepsis Kills program including designing and implementing a clinical alert system for identifying and predicting sepsis earlier, review member and lead for several root-cause analyses teams, systems review post-safety incidents across NSW.\no State-wide NSW Emergency care institute Research unit medical chair and member of national emergency research committee\n### · WSLHD\no Designed, developed and implemented the direct admission at home model of care for hospital in the home services in Western Sydney\no Designed and implemented Westmead hospital emergency department novel models of care\no Currently leading research initiatives and funding grants in WSLHD themed on use of information technology in healthcare\n# Education\n### Fellow of Australasian College for Emergency Medicine (FACEM) (2012). AHPRA Medical practitioner with general and specialist registration\n### Bachelor of Medicine, Bachelor of Surgery (MBBS) University of Mumbai (1998)\n### \n### International program for Physician Leadership development at Institute for Healthcare Improvement (IHI, Boston) and Harvard School for Public Health, May 2016.\n### Doctor of Philosophy (PhD) University of Sydney (2020) Sepsis screening pathways in Emergency departments.\n### Certificate in Managing Health Care Delivery from Harvard Business School (2020-2021)\n### Certificates in Leadership strategies in Information Technology in Healthcare (2014), Healthcare Project Management (2012), from Harvard School for Public Health.\n### Certificates in Authentic Leadership from London Business School and Leading Innovation at Harvard Business School (part I/III of certificate in management excellence at HBS).\n \n \n**Research and publications**\n**_Key research themes: Models of care, Point of care testing, work-flows and algorithms, risk stratification and patient outcomes and experience measures_**\n**_Publications: top cited _**\n Authors\n Title\n Publication\n Volume\nNumber\nPages\nYear\n Citations\n Shetty, Amith; Gunja, Naren; Byth, Karen; Vukasovic, Matthew; \n Senior streaming assessment further evaluation after triage zone: a novel model of care encompassing various emergency department throughput measures\n Emergency Medicine Australasia\n 24\n4\n374-382\n2012\n 36\n Perveen, Shuhana; Unwin, Danielle; Shetty, Amith Loknath; \n Point of care D-dimer testing in the emergency department: a bioequivalence study\n Annals of laboratory medicine\n 33\n1\n34-38\n2013\n 19\n Grewal, Harjeet; Varshney, Kavita; Thomas, Lee C; Kok, Jen; Shetty, Amith; \n Blood pressure cuffs as a vector for transmission of multi‐resistant organisms: Colonisation rates and effects of disinfection\n Emergency Medicine Australasia\n 25\n3\n222-226\n2013\n 9\n Vaghasiya, Milan R; Murphy, Margaret; O’Flynn, Daniel; Shetty, Amith; \n The emergency department prediction of disposition (EPOD) study\n Australasian Emergency Nursing Journal\n 17\n4\n161-166\n2014\n 13\n Denver, Dominique; Shetty, Amith; Unwin, Danielle; \n Falls and implementation of NEXUS in the elderly (The FINE Study)\n The Journal of emergency medicine\n 49\n3\n294-300\n2015\n 17\n Shetty, Amith L; Brown, Tristam; Booth, Tarra; Van, Kim Linh; Dor‐Shiffer, Daphna E; Vaghasiya, Milan R; Eccleston, Cassanne E; Iredell, Jonathan; \n Systemic inflammatory response syndrome‐based severe sepsis screening algorithms in emergency department patients with suspected sepsis\n Emergency Medicine Australasia\n 28\n3\n287-294\n2016\n 8\n Macdonald, Stephen PJ; Williams, Julian M; Shetty, Amith; Bellomo, Rinaldo; Finfer, Simon; Shapiro, Nathan; Keijzers, Gerben; \n Sepsis in the emergency department–Part 1: Definitions and outcomes\n Emergency Medicine Australasia\n 29\n6\n619-625\n2017\n 14\n Shetty, Amith; MacDonald, Stephen PJ; Williams, Julian M; van Bockxmeer, John; de Groot, Bas; Esteve Cuevas, Laura M; Ansems, Annemieke; Green, Malcolm; Thompson, Kelly; Lander, Harvey; \n Lactate≥ 2 mmol/L plus qSOFA improves utility over qSOFA alone in emergency department patients presenting with suspected sepsis\n Emergency Medicine Australasia\n 29\n6\n626-634\n2017\n 16\n Shetty, Amith L; Thompson, Kelly; Byth, Karen; Macaskill, Petra; Green, Malcolm; Fullick, Mary; Lander, Harvey; Iredell, Jonathan; \n Serum lactate cut-offs as a risk stratification tool for in-hospital adverse outcomes in emergency department patients screened for suspected sepsis\n BMJ open\n 8\n1\ne015492\n2018\n 11\n Shetty, Amith; Macdonald, Stephen PJ; Keijzers, Gerben; Williams, Julian M; Tang, Benjamin; De Groot, Bas; Thompson, Kelly; Fraser, John F; Finfer, Simon; Bellomo, Rinaldo; \n Sepsis in the emergency department–Part 2: Investigations and monitoring\n Emergency Medicine Australasia\n 30\n1\n4-Dec\n2018\n 11\n \n** **\n**Publications for Amith Shetty**\n**2019**\nHerwanto, V., Shetty, A., Nalos, M., Chakraborty, M., McLean, A., Eslick, G., Tang, B. (2019). Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality in 121 Studies Including 1,716,017 Individuals: A Systematic Review and Meta-Analysis. _Critical Care Explorations_, 1(9), 1-9. [More Information]\nShaw, T., Janssen, A., Crampton, R., O'Leary, F., Hoyle, P., Jones, A., Shetty, A., Gunja, N., Ritchie, A., Spallek, H., Solman, A., Kay, J., Makeham, M., et al (2019). Attitudes of health professionals to using routinely collected clinical data for performance feedback and personalised professional development. _Medical Journal of Australia_, 210(S6), S17-S21. [More Information]\nLi, L., Rathnayake, K., Green, M., Fullick, M., Shetty, A., Walter, S., Braithwaite, J., Lander, H., Westbrook, J. (2019). Improving the Performance of Clinical Decision Support for Early Detection of Sepsis: A Retrospective Observational Cohort Study. _Studies in Health Technology and Informatics_, 264, 679-683. [More Information]\nNguyen, H., Rebbeck, T., Kifley, A., Jagnoor, J., Dinh, M., Shetty, A., Nicholas, M., Cameron, I. (2019). Positive recovery for low-risk injuries screened by the short form-Orebro musculoskeletal pain screening questionnaire following road traffic injury: Evidence from an inception cohort study in New South Wales, Australia. _BMC Musculoskeletal Disorders_, 20(1), 1-10. [More Information]\nCoggins, A., Nottingham, C., Byth, K., Ho, K., Aulia, F., Murphy, M., Shetty, A., Todd, A., Moore, N. (2019). Randomised controlled trial of simulation-based education for mechanical cardiopulmonary resuscitation training. _Emergency Medicine Journal_, 36(5), 266-272. [More Information]\nChow, M., Nikolic, S., Shetty, A., Lai, K. (2019). Structured Interdisciplinary Bedside Rounds in an Australian tertiary hospital emergency department: Patient satisfaction and staff perspectives. _EMA - Emergency Medicine Australasia_, 31(3), 347-354. [More Information]\nNoori, O., Jackson, M., Shetty, A., Medlow, S., Steinbeck, K. (2019). Transition care and the emergency department. _EMA - Emergency Medicine Australasia_, 31(6), 1125-1127. [More Information]\n**2018**\nPavic, K., Pandya, J., Sebak, S., Shetty, A., Manolios, N. (2018). Acute arthritis: predictive factors and current practice in the approach to diagnosis and management across two hospitals in Sydney. _Internal Medicine Journal_, 48(9), 1087-1095. [More Information]\nShetty, A., Sparenberg, S., Adams, K., Selvedran, S., Tang, B., Hanna, K., Iredell, J. (2018). Arterial to end-tidal carbon dioxide tension difference (CO2 gap) as a prognostic marker for adverse outcomes in emergency department patients presenting with suspected sepsis. _EMA - Emergency Medicine Australasia_, 30(6), 794-801. [More Information]\nBrown, T., Shetty, A., Zhao, D., Harvey, N., Yu, T., Murphy, M. (2018). Association between pain control and patient satisfaction outcomes in the emergency department setting. _EMA - Emergency Medicine Australasia_, 30(4), 523-529. [More Information]\nShetty, A., MACDONALD, S., Keijzers, G., Williams, J., Tang, B., De Groot, B., Thompson, K., Fraser, J., Finfer, S., Bellomo, R., Iredell, J. (2018). Review article: Sepsis in the emergency department - Part 2: Investigations and monitoring. _EMA - Emergency Medicine Australasia_, 30(1), 4-12. [More Information]\nWilliams, J., Keijzers, G., MacDonald, S., Shetty, A., Fraser, J. (2018). Review article: Sepsis in the emergency department - Part 3: Treatment. _EMA - Emergency Medicine Australasia_, 30(2), 144-151. [More Information]\nShetty, A., Thompson, K., Byth Wilson, K., Macaskill, P., Green, M., Fullick, M., Lander, H., Iredell, J. (2018). Serum lactate cut-offs as a risk stratification tool for in-hospital adverse outcomes in emergency department patients screened for suspected sepsis. _BMJ Open_, 8(1), 1-8. [More Information]\nWarmerdam, M., Baris, L., Liebergen, M., Ansems, A., Exteve Cuevas, L., Willeboer, M., Rijpsma, D., Shetty, A., De Groot, B. (2018). The association between systolic blood pressure and in-hospital mortality in older emergency department patients who are hospitalised with a suspected infection. _Emergency Medicine Journal_, 35(10), 619-622. [More Information]\n**2017**\nNoori, O., Batra, S., Shetty, A., Steinbeck, K. (2017). Adolescent presentations to an adult hospital emergency department. _EMA - Emergency Medicine Australasia_, 29(5), 539-544. [More Information]\nShetty, A., Teh, C., Vukasovic, M., Joyce, S., Vaghasiya, M., Forero, R. (2017). Impact of emergency department discharge stream short stay unit performance and hospital bed occupancy rates on access and patient flow measures: A single site study. _EMA - Emergency Medicine Australasia_, 29(4), 407-414. [More Information]\nShetty, A., MACDONALD, S., Williams, J., Van Bockxmeer, J., De Groot, B., Exteve Cuevas, L., Ansems, A., Green, M., Thompson, K., Lander, H., et al (2017). Lactate (>=)2 mmol/L plus qSOFA improves utility over qSOFA alone in emergency department patients presenting with suspected sepsis. _EMA - Emergency Medicine Australasia_, 29(6), 626-634. [More Information]\nFullerton, J., Thompson, K., Shetty, A., Iredell, J., Lander, H., Myburgh, J., Finfer, S. (2017). New sepsis definition changes incidence of sepsis in the intensive care unit. _Critical Care and Resuscitation_, 19(1), 9-13.\nFullerton, J., Thompson, K., Shetty, A., Iredell, J., Lander, H., Myburgh, J., Finfer, S. (2017). New sepsis definition changes incidence of sepsis in the intensive care unit. _Critical Care and Resuscitation_, 19(1), 9-13.\nMACDONALD, S., Williams, J., Shetty, A., Bellomo, R., Finfer, S., Shapiro, N., Keijzers, G. (2017). Review article: Sepsis in the emergency department � Part 1: Definitions and outcomes. _EMA - Emergency Medicine Australasia_, 29(6), 619-625. [More Information]\n**2016**\nNoori, O., Shetty, A., Steinbeck, K. (2016). Adolescent presentations to adult hospital emergency departments: systematic review. _Jacobs Journal of Emergency Medicine_, 3(4), 1-7.\nTse, R., Thompson, N., Moscova, M., Sindhusake, D., Shetty, A., Young, N. (2016). Do delays in radiology lead to breaches in the 4-hour rule? _Clinical Radiology_, 71(6), 523-531. [More Information]\nShetty, A., Vaghasiya, M., Boddy, R., Byth Wilson, K., Unwin, D. (2016). Perceived incivility during emergency department phone consultations. _EMA - Emergency Medicine Australasia_, 28(3), 256-261. [More Information]\nShetty, A., Brown, T., Booth, T., Van, K., Dor-Shiffer, D., Vaghasiya, M., Eccleston, C., Iredell, J. (2016). Systemic inflammatory response syndrome-based severe sepsis screening algorithms in emergency department patients with suspected sepsis. _EMA - Emergency Medicine Australasia_, 28(3), 287-294. [More Information]\n**2015**\nYee, K., Shetty, A., Lai, K. (2015). ABG needle study: a randomised control study comparing 23G versus 25G needle success and pain scores. _Emergency Medicine Journal_, 32(5), 343-347. [More Information]\nShetty, A., Shankar Raju, S., Hermiz, A., Vaghasiya, M., Vukasovic, M. (2015). Age and admission times as predictive factors for failure of admissions to discharge-stream short-stay units. _EMA - Emergency Medicine Australasia_, 27(1), 42-46. [More Information]\nDenver, D., Shetty, A., Unwin, D. (2015). Falls and Implementation of NEXUS in the Elderly (The FINE Study). _The Journal of Emergency Medicine_, 49(3), 294-300. [More Information]\n**2014**\nPerveen, S., Unwin, D., Shetty, A., Byth Wilson, K. (2014). Response to the comments on 'point of care D-dimer testing in the emergency department-A bioequivalence study' and erratum to the results. _Annals of Laboratory Medicine_, 34(1), 66-67. [More Information]\nVaghasiya, M., Murphy, M., O'Flynn, D., Shetty, A. (2014). The emergency department prediction of disposition (EPOD) study. _Australasian Emergency Nursing Journal_, 17(4), 161-166. [More Information]\n**2013**\nRafi, M., Shetty, A., Gunja, N. (2013). Accuracy of computed tomography of the kidneys, ureters and bladder interpretation by emergency physicians. _EMA - Emergency Medicine Australasia_, 25(5), 422-426. [More Information]\nGrewal, H., Varshney, K., Thomas, L., Kok, J., Shetty, A. (2013). Blood pressure cuffs as a vector for transmission of multi-resistant organisms: colonisation rates and effects of disinfection. _EMA - Emergency Medicine Australasia_, 25(3), 222-226. [More Information]\nPerveen, S., Unwin, D., Shetty, A. (2013). Point of Care D-Dimer Testing in the Emergency Department: A Bioequivalence Study. _Annals of Laboratory Medicine_, 33(1), 34-38. [More Information]\n**2012**\nShetty, A., Gunja, N., Byth Wilson, K., Vukasovic, M. (2012). Senior Streaming Assessment Further Evaluation after Triage zone: A novel model of care encompassing various emergency department throughput measures. _EMA - Emergency Medicine Australasia_, 24(4), 374-382. [More Information]\n**2010**\nShetty, A., Lai, K., Byth, K. (2010). The CO2 GAP Project-CO2 GAP as a prognostic tool in emergency departments. _EMA - Emergency Medicine Australasia_, 22(6), 524-531. [More Information]\n** **\n** **\n**Current ongoing research projects**\n· **BLISS 2 trial **– Bacterial load in severe sepsis trial – site lead for this multicentre trial\n· **SMEDSA **(Sydney Multicentre Emergency Department Sepsis Archive) – Project lead/ Chief investigator for development and analysis of patients presenting to ED – multicentre trial – multiple studies\n• **Key big data project evaluations in Sepsis**\n• **Algorithms for screening**\n• **Performance of existing algorithms for screening, severity scores**\n• **Evaluations of bundles of sepsis care and interventions – time to antibiotics. IV fluids**\n• **Age-based cut-off of thresholds**\n• **Sex-based sepsis epidemiology**\n• **Cost of Sepsis in NSW**\n· **Manual CPR, Manual CPR with feedback and Mechanical CPR in simulation **– randomised trial\n· **Alcohol Harm in Emergency Department Study **– Research lead for Westmead hospital for multicentre trial (Australia and New Zealand)\n· **ED/ Hospital in the home costing costing study **– Independent Hospital Pricing Authority led ED level patient care costing study\n· **Motor Traffic Authority **– clinical lead for Westmead hospital – sociodemographic factors in chronic head injury outcomes\n· **Domestic violence in Emergency department **– current practice and future policy impacts\n· **Adolescent presentations to co-located adults and paediatrics hospitals **– qualitative analysis of transitional care.\n· **ED ETP correlation to sepsis, hospital outcomes**\n· **ED ETP correlation to hospital occupancy, access block and ESSU performance**\n· **Impact of SAFE-t zone and trauma pathways on radiology test ordering.**\n· **Developing an retrospective data-based algorithm to predict impacts of different staffing patterns on emergency department waiting times**\n","Slug::Auto":"amith-shetty","recordId":"recDfiHs4NDv9xQhw","Profile Image URL":"https://dl.phage.directory/.attachments/89ee16272884255bcac0d4dff01b3456/ed9fdfd6/CD063_email.jpg","Editable Form Link":{"label":"Form Edit 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Having witnessed the detrimental effects and increasing incidences of multidrug resistant bacterial infections throughout my time there, I became passionate to address multidrug resistance bacterial infections in clinical settings, and this spurred me to start a PhD this that is exploring the potential of bacteriophages to treat antibiotic resistant _Pseudomonas aeruginosa_ lung infections in children with cystic fibrosis.\nI was awarded a number of competitive scholarships to facilitate my studies including the UWA and Graduate Women (WA) Research Scholarship, The CFWA Golf Classic Scholarship, Wesfarmers Centre for Vaccines and Infectious Diseases HDR Scholarship and the Geoffrey Kennedy Convocation Postgraduate Research Travel Award. 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She then moved to Australia to continue her postdoctoral career under the supervision of Prof. Jonathan Iredell. Since 2018, Alex has been working as a lead phage scientist in the world’s first-in-human clinical trial of intravenous GMP-grade phage therapy (Petrovic-Fabijan et al, 2020 Nature Microbiology), where she studied bacteria-phage interaction and host response in critically ill patients receiving phage therapy. Alex has been recently awarded a 3-year (2022-24) fellowship from Office for Health and Medical Research NSW ($390k) that will support her research on bacterial cell and phage biology, with a special focus on interactions between clinically important bacteria such as L-forms and therapeutic phages. Alex is leading a lab side of Mycobacterium phage therapy at Westmead (Iredell Lab), developing diagnostic methods for therapeutic monitoring of phages and pioneering more accurate and reliable approaches for testing antimicrobial agents in vitro. 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His project is focused on phage resistance evolution by Pseudomonas aeruginosa.","Category":["Associate Investigator"],"Name":"Andrew Vaitekenas","Profile":[{"id":"attrmui7YQnRHhW62","width":400,"height":600,"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/4UablCkPATZVNPCKtj78iQ/UGCTTZoT88JcSCWOLAeI4SPhvkRovEaPO60gHrU9faQ_5y5qmuV-DCcza3aLV-N7vRJUvSLCFfjK2G59GSIxU9tq_DLJcEh--YbhRItiFhU/HE-6TF1FyY8ms1dxJA0nhu1SgDY-Y_ufsLFJ9krPxCQ","filename":"andrew.jpg","size":36103,"type":"image/jpeg","thumbnails":{"small":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/YI9-0MK8JqTgv15e1xC4lg/hZJu08nvFWWy-FpHS593wOAL4x5mBcsL6eRYk7Q2EXGw13KBTCfei9UqvoNGfXvPw8sIkJFqP4QOyc5TjbfAEw/2u_ezv8SIG-6V27M9wOWo2H-FUJvnH7iQ3V3XbXlB9w","width":24,"height":36},"large":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/wvCLZtvEeMjl8eAAwU8x5Q/zuQrHYG4EuxNCDZGRRHp82UjRQxqzqzZBju1q8QRBYjjQnKOXFVAMhPC2HUvKbRk4LScBcF9d6GCRd-aqkpd1g/Twx4-lee9xtsxnxpubc2wO0zYb2x_7aWMjaGuS4qbxU","width":400,"height":600},"full":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/Gv8cCQaIWT9I6dGkIGRbRg/HTc5m08QVyzqpTs2dvS0RDn_tNK0bOPOPNcYV8vGpNgpaINNuQokyU_qPH-IfHG-2uNJz6p-Itnl2jMIDWhFPg/0GVypEyIP6Pe7I_eUQGwUcqHGqbe5wKe4e4Ukbmj3HU","width":3000,"height":3000}}}],"Linked Profiles":["reczwlAbqUSdoVbEa","rect3pR6t66HevteG"],"Position":"PhD Student","Affiliation":"School of Public Health, Curtin University/ Telethon Kids Insitute","Title":"Mr","Status":"Published","Last name":"Baitekenas","Slug":"andrew-baitekenas","Twitter":"https://twitter.com/AVaitekenas","Location":"Victoria","Description":"Andrew graduated from Curtin University in 2019 with first class honours and a high distinction in Molecular Genetics and Biotechnology. He was also twice a member of the Curtin Vice Chancellor’s list. Andrew started a PhD in 2020 at the Wal-yan Respiratory Research Centre on a project entitled “Elucidating and Utilising the Mechanisms Used by _Pseudomonas aeruginosa_ to Develop Resistance to Bacteriophages to Aid Therapeutic Formulation and Application in Cystic Fibrosis” and was successful in receiving scholarship support through a Curtin RTP Scholarship (2020-2023). He has also been awarded a Cystic Fibrosis Australia postgraduate studentship grant (2020-2021), Cystic Fibrosis Western Australia Golf Classic scholarship (2021-2023) and Wesfarmers Centre of Vaccines and Infectious Diseases and Wal-Yan Respiratory Centre top up scholarship (2021-2023).\nDuring his project Andrew has isolated >250 phages from wastewater. The isolated phages had their host range tested against a large range of _P. aeruginosa _derived from diverse clinical settings, allowing the selection of the top 20 phages with broadest host range. The top 20 phages had the receptor they use determined, stability to different temperatures and pH evaluated and had their genomes characterised bioinformatically. Phages from the top 20 that have the potential for phage therapy have been identified. Four distinct phages were evaluated more closely both functionally by one-step growth curve and morphologically through transmission electron microscopy. Andrew has since gone on to investigate the kinetics of phage resistance development by CF clinical isolates of _P. aeruginosa _after treatment with the four phages at different doses over time. The phage resistant bacteria will be sequenced to determine the genetic causes of resistance. The trade-offs of phage resistance to growth, antibiotic susceptibility, motility, biofilm formation and pigment production will also be investigated. This work will be amongst the first to investigate the evolution of phage resistance by CF clinical isolates and to compare phage resistance evolution by adult- and childhood-derived _P. aeruginosa _isolates. The mechanisms of resistance and trade-offs will then be exploited to strategically formulate phage cocktails capable of suppressing phage resistance to ensure phage therapy remains effective. Formulated cocktails will be used to treat _P. aeruginosa _infections of primary airway epithelial cells to investigate _in vitro _safety and efficacy. This work will be amongst the first to investigate primary airway epithelial cell responses to phages and will aid in the determination of the formulated cocktail’s safety and effectiveness. \nWork conducted has resulted in several publications already and he has presented his work at three international, two national, and three state conferences including an oral presentation at the European Cystic Fibrosis Conference (2021) and has been awarded a travel award from the World Microbe Forum (2021).\n","Slug::Auto":"andrew-vaitekenas","recordId":"recY6wiOjhuvCs5Fo","Profile Image URL":"https://dl.phage.directory/.attachments/ba9adc789fefbb05513ac935c5bd5a51/c5105991/andrew.jpg","Editable Form Link":{"label":"Form Edit 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She is a Postdoctoral Associate at the Sydney School of Veterinary Science, The University of Sydney.","Category":["Associate Investigator"],"Name":"Carola Venturini","Profile":[{"id":"attVADU7R7yfCV41W","width":900,"height":1059,"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/upfbe_2izKMA95bkaK1xPw/p4p4vLzJV28TM7vYc3R_akAf0pfm4BKnBBFFwHZQszf0BG05n_tlQ7VyZY84MjYMPDRDY_8ztSz958k4OslUt-25CHczLWKvhn-ObHgaQkY/zqU-9yrxgyyXUDftaMvPlT-_9hyn5HNFMH3HQbvaYBU","filename":"20220603_170304.jpg","size":55240,"type":"image/jpeg","thumbnails":{"small":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/cY6yhQi-Edfn4iOwg6mrzg/_h4gkRnKt7Hcf4zgpbYfuqKSAGALllUaGGi7qIvm_5p5WnBIxwYYQjecduJzv88jujOa3FtoHg2h_8SgcnxOuA/dha2uoheaWfFHD26DdH0h2q1neKBB8Af_rFW6-4lRVg","width":31,"height":36},"large":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/X4uOc7u3haUvd7g_5UeFUw/1Um3-NadfdW4BroTezP_YTW7IU0MIDCSxNIQSb-LxTb7jQ26crkZWkpQLBH0CNqyl2gcJtEmTZOALAZOmK6-NQ/cr290DjczH8s-vSjyQJf_CINAiKpGSK5PlQjkTWQyC4","width":512,"height":602},"full":{"url":"https://v5.airtableusercontent.com/v1/17/17/1684468800000/KwnFN9FtEz-N7BhRnzzOBA/FGcRJ7oQUmInJvj7ivT0LOMJi4bu_Ha5J9pBs14oLV5lEqFrIKrEpQ4MU1wJY-HiHnme9cLaSHAf4t6BmEwINA/9w8EudD4XJ0kC1j8W4SqcuDtvePGkmOzaVhHJmD6YUo","width":3000,"height":3000}}}],"Linked Profiles":["recrVq0k7wusEZKZS"],"Position":"Postdoc","Affiliation":"Sydney Uni","Title":"Dr ","Status":"Published","Last name":"Venturini","Slug":"carola-venturini","Twitter":"https://twitter.com/CarolaVenturini","Location":"Sydney, Australia","Description":"Dr Venturini is an experienced microbiologist with clinical and basic science research expertise. Her primary research focus is the role of mobile genetic elements (incl. phages) in the evolution of clinically relevant pathogens. Dr Venturini has strong multidisciplinary expertise in lab-based experimental microbiology, animal trials, molecular biology, and microbial genomics (bacterial/phage genomics and metagenomics). In her PhD (2012; UOW, NSW DPI) and early Postdoc (2010-2013; UOW, UQ), Dr Venturini started exploring the relationship between antibiotic resistance, virulence and mobile DNA (plasmid; phage) in multidrug resistant pathogenic bacteria. 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